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Scaling Up Point-of-Care Genetic Testing in the VA: A Nurse-Led Initiative - Kara Maxwell Details Kara Maxwell shares insights about the groundbreaking work she and her team have been undertaking in germline genetic testing. Supported by PCF funds, they aim to bolster genetic testing programs for patients within the VA system and beyond. Notably, Dr. Maxwell praises the contributions of her colleague, Dr. Lisa Aiello, a skilled PhD-trained nurse, who has been instrumental in establishing a poi...
Exploring the PROSPER Study: A Neoadjuvant Approach to Kidney Cancer - Mohamad Allaf Details Alicia Morgans engages in a discussion with Mohamad Allaf about the PROSPER Study, an ECOG investigation focused on a neoadjuvant perioperative approach to treating high-risk kidney cancer. The conversation delves into the study's rationale and design, exploring the collaboration between medical oncologists and urologists. Dr. Allaf details the premise of the study, highlighting the implementation...
The AFT-19 Study: A Comprehensive Look at High-Risk Prostate Cancer Treatment - Rahul Aggarwal Details Rahul Aggarwal speaks with Alicia Morgans about the completed phase III trial AFT-19 for high-risk biochemically relapsed prostate cancer patients. The trial explored three arms: ADT alone, ADT plus apalutamide, and a triplet of ADT, apalutamide, and abiraterone, with a primary endpoint of PSA progression-free survival. Results showed significant prolongation of PSA progression-free survival in bo...
Exploring the Nuances of the PRONOUNCE Trial - Celestia Higano Details Alicia Morgans and Tia Higano discuss the PRONOUNCE trial, which evaluates the effects of degarelix and leuprolide on cardiovascular events in high-risk prostate cancer patients. Dr. Higano offers insightful explanations concerning the trial's methodology, highlighting its initial slow accrual and early cessation due to a futility analysis. However, she points out that the trial's results, which s...
Navigating the Challenges of Somatic Mutation Testing in Prostate Cancer - Joaquin Mateo Details Alicia Morgans engages with Joaquin Mateo to discuss the clinically relevant challenges and approaches to somatic mutation testing in advanced prostate cancer patients. They address the difficulties in obtaining adequate tissue for testing, the concordance between different testing mechanisms, and the balance between ideal plans and clinical feasibility. Dr. Mateo emphasizes the importance of unde...
A Journey Through Prostate Cancer Research: Perspective on the Prostate Cancer Foundation's Impact - Philip Kantoff Details Alicia Morgans interviews Phil Kantoff to discuss the Prostate Cancer Foundation’s (PCF) evolution, significant achievements, and future directions. Dr. Kantoff recounts the early challenges of prostate cancer research, including the lack of funding and interest from the pharmaceutical industry. PCF's strategic initiatives, such as small grants and the Young Investigator Award, attracted a critica...