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- Alicia Morgans is joined by Elisabeth Heath of the Karmanos Cancer Institute in a discussion on disparities in prostate cancer focusing on the barriers in enrolling African American men with prostate cancer in clinical trials. The National Cancer Institute recognizes this problem and has offices of health equity and community engagement in all NCI-designated cancer centers. Heath highlights some o...
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- Samuel Denmeade, Co-Director of the Johns Hopkins Prostate Cancer Program joins Alicia Morgans in a discussion on Bipolar Androgen Therapy (BAT) for prostate cancer. ADT slows prostate cancer’s progress by shutting off testosterone. Eventually, cancer adapts to this new environment and PSA levels start to rise. The concept of BAT is for men whose prostate cancer has become resistant to standard ho...
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- Martin Sjöström discusses his groundbreaking research on liquid biopsy biomarkers in prostate cancer. Dr. Sjöström’s team is developing a platform that uses the epigenetic modification, 5-hydroxymethylcytosine (5hmC), found in cell-free DNA circulating in the blood, to predict a patient's response to therapy and detect treatment resistance earlier. The novel approach provides broader and more comp...
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- Alicia Morgans and Emmanuel Antonarakis discuss an ongoing biomarker analysis aimed at identifying a molecular signature predictive of response in the COMBAT study. The COMBAT study is a multi-center, single-arm, open label Phase 2 study in asymptomatic patients with mCRPC who had soft tissue metastases amenable to biopsy, and who progressed on at least one prior novel AR-targeted therapy (and up...
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- Josh Lang joins Alicia Morgans in a discussion on the importance of understanding mechanisms of resistance to targeted therapies through the development of novel liquid biopsies of the human tumor microenvironment. Lang highlights his research which looks beyond tissue biopsy to liquid biopsies of cancer cells from a blood draw to inform decision-making. Research funded by the Prostate Cancer Foun...
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- Researcher and associate professor Isla Garraway joins Alicia Morgans in a discussion on ongoing prostate cancer research and current initiatives in the Veteran's Affairs (VA) Care Program. With support from the Prostate Cancer Foundation (PCF) Garraway is part of a team of physician-scientists working to ensure our veterans have access to the same precision oncology medications and clinical trial...
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- Renu Eapen, a recipient of the PCF Young Investigator Award, details her groundbreaking project on early use of Lutetium PSMA for high-risk localized prostate cancer. The two-cohort clinical trial involves administering Lutetium PSMA upfront, followed by radical prostatectomy. An integral part of the study is the translational work, analyzing changes in the tumor microenvironment in response to Lu...
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- Leanne Woods-Burnham discusses her 2020 Young Investigator Award project with the Prostate Cancer Foundation, focusing on prostate cancer disparities, especially among black men. Her research looks at HER2 expression and its connection to West African ancestry. She explains that HER2 is correlated with this ancestry, rather than self-reported race. The project involves RNA sequencing on tumor tiss...
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- Alicia Morgans converses with Neeraj Agarwal about the ongoing phase III Contact-02 Trial, designed for patients with metastatic castrate-resistant prostate cancer (CRPC) who show disease progression on a novel hormonal therapy or androgen receptor inhibitor. Patients eligible for this trial should have measurable disease, which may include extra pelvic lymphadenopathy or visceral metastasis. Dr....
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- Alicia Morgans speaks with Sophia Kamran, who won the Young Investigator Award in 2021. Dr. Kamran shares her research into the potentially beneficial role of radiation in treating oligometastatic prostate cancer, a field where much remains unknown. She is particularly focused on defining the disease more biologically, while also examining the complex interaction of radiation with the immune syste...
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