- Details
- Fred Saad and Neal Shore discuss the ARANOTE trial with Zach Klaassen, exploring the use of darolutamide plus ADT in metastatic hormone-sensitive prostate cancer. They highlight the trial's diverse patient population and impressive results, including a 46% reduction in radiographic progression-free survival risk. The conversation covers the efficacy of this doublet therapy in various subgroups, pa...
|
- Details
- Neeraj Agarwal interviews Niven Mehra about the INSPIRE trial. The study examines the efficacy of nivolumab and ipilimumab combination therapy in molecularly selected patients with metastatic castration-resistant prostate cancer (mCRPC). Dr. Mehra discusses the trial's design, which focuses on four subgroups: mismatch repair deficiency, high tumor mutational burden, CDK12 inactivation, and BRCA2 m...
|
- Details
- Leslie Ballas interviews Syed Hussain about histologic subtypes of bladder cancer. Dr. Hussain discusses the challenges in diagnosing and managing variant histologies, emphasizing their poor prognosis and the need for specialized research. He highlights the importance of central pathology review and the potential differences in treatment response among subtypes. Dr. Hussain advocates for focused i...
|
- Details
- Sam Chang interviews Ignacio Duran about the highlights of ESMO 2024 in non-prostate genitourinary oncology. Dr. Duran discusses key findings in kidney and bladder cancer. For kidney cancer, he highlights studies challenging the sequencing of checkpoint inhibitors and new treatment options for non-clear cell carcinoma. In bladder cancer, Dr. Duran reviews three studies that could impact clinical p...
|
- Details
- Oliver Sartor interviews William Kevin Kelly about findings on AMG 509 (Xaluritamig), a STEAP1-targeted T-cell engager for advanced prostate cancer. Dr. Kelly discusses the drug's mechanism, dosing optimization, and efficacy in heavily pretreated patients. He highlights the manageable cytokine release syndrome and the need to address musculoskeletal side effects. The conversation covers impressive...
|
- Details
- Himisha Beltran discuses DLL3, a promising target for neuroendocrine prostate cancer treatment. Dr. Beltran explains that DLL3 is highly expressed in neuroendocrine and small cell prostate cancers, making it an attractive therapeutic target. She reviews recent clinical trials of DLL3-targeted T-cell engagers, including Tarlatamab and MK-6070, highlighting their potential efficacy in treating neuro...
|
- Details
- Oliver Sartor hosts Jake Berchuck to discuss a novel epigenomic liquid biopsy platform for determining PSMA expression in prostate cancer. Dr. Berchuck explains how the assay analyzes cell-free DNA to infer tumor PSMA expression, showing strong correlation with PSMA PET scan results. They explore the potential of this technology to provide real-time, non-invasive monitoring of tumor drug target ex...
|
- Details
- Leslie Ballas and Tian Zhang discuss the STAR-EV trial, a new study combining enfortumab vedotin (EV) and radiation for muscle-invasive bladder cancer patients ineligible for cisplatin. Dr. Zhang outlines the trial's design, which uses three EV cycles followed by targeted radiation and cystectomy. The study aims to improve complete response rates from 36% with EV alone to 60% with the combination....
|
- Details
- Cora Sternberg discusses her presentation on event-free survival (EFS) as a surrogate endpoint for overall survival in muscle-invasive bladder cancer. Dr. Sternberg explains the study's methodology, which analyzed 15 clinical trials evaluating neoadjuvant treatments followed by radical cystectomy. The research demonstrates a strong association between EFS and overall survival, supporting EFS as a...
|
- Details
- Oliver Sartor and Ken Herrmann discuss the current state and future directions of PSMA ligand therapy in prostate cancer treatment. Dr. Herrmann presents recent findings from various clinical trials, including PSMAfore and ENZA-p, which explore the use of lutetium-PSMA therapy in different stages of prostate cancer. They examine the potential of combining lutetium-PSMA with other treatments like e...
|
