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- In this informative presentation from Andrea Necchi, MD, he presents information related to his goal of finding bladder-sparing treatment options for muscle-invasive bladder cancer (MIBC). Dr. Necchi begins his presentation with a discussion on recent immunotherapy studies for MIBC, the Balar, and IMMUNOPRESERVE studies. He presents evidence that both of these trials have displayed a promising amo...
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- Eugene Pietzak, MD, Assistant Attending Surgeon of Urologic Oncology at Memorial Sloan Kettering Cancer Center in New York City received one of the five 2021 Bladder Cancer Advocacy Network (BCAN) New Discoveries Young Investigator Awards for his work in “Defining the Clinical Impact and Molecular Drivers of ‘Secondary’ Muscle-Invasive Bladder Cancer.” There are relatively well-established molecul...
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- In a presentation, followed by an educational discussion, from Reza Mehrazin, MD, the topic of management of primary urothelial carcinoma is discussed in depth. Dr. Mehrazin began his presentation with epidemiology and risk factors for this aggressive disease. He discussed the risk factor of advanced age (> 60 years old) along with other less-known risk factors, such as chronic urethral irritation...
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- Ashish Kamat hosts Manjiri Dighe for a discussion on the evolving role of radiology in bladder cancer diagnosis and staging. Dr. Dighe elaborates on the limitations and advancements in imaging techniques like CT scans, MRI, and ultrasound, emphasizing their increasing importance for assessing local tumor invasion and lymph node spread. The conversation also delves into the potential of newer metho...
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- In this UroToday discussion between Bishoy Faltas and Sam Chang, the pair discuss recent data that is emerging in the role of germline mutations in bladder cancer patients. Dr. Faltas provides his insight for identifying deleterious germline variance from whole-exome sequencing data and highlights the results of the analysis of the functional impact of these germline variants on protein structure...
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- Svetlana Avulova, MD, Urologic Oncology Fellow at Mayo Clinic received the 2021 BCAN New Discoveries Young Investigator Award for Patient-Centered Research. In this conversation with Ashish Kamat, MD she highlights her project titled “Sexual Function in Women Undergoing Radical Cystectomy”. There is a lack of research on women's quality of life, specifically, on the effect of radical cystectomy on...
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- In this conversation with Alicia Morgans, MD, MPH, Arjun Balar, MD highlights a multicenter study first designed in 2014 of gemcitabine hypofractionated radiation therapy and pembrolizumab all in combination as bladder-sparing therapy for patients with muscle-invasive bladder cancer that had a total of 54 patients. The goal of the study was to test the role of immunotherapy pembrolizumab added to...
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- With the oncological safety of TURBT unknown, staging inaccuracies are commonplace, and correct treatment of muscle-invasive bladder cancer is potentially delayed. The BladderPath study is looking at using a multiparametric magnetic resonance imaging (mpMRI) scan to diagnose bladder cancer that has grown into the muscle. Drs. Jim Catto and Gary Steinberg join Dr. Ashish Kamat in a discussion about...
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- Yair Lotan joins Ashish Kamat in a slide presentation discussion on urine markers for hematuria and bladder cancer. Dr. Lotan overviews a number of recently published papers and new studies in this space. He highlights limitations and challenges with cytology, the current role of markers and where they stand in clinical use, and urinary markers that are available as well as in development for pati...
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- Ashish Kamat hosts Janet Kukreja to discuss intravesical therapy for bladder cancer, providing a comprehensive overview of treatments such as BCG, gemcitabine, and mitomycin C. Dr. Kukreja emphasizes the importance of understanding patient risk categories and adhering to guidelines for treatment decisions. She addresses the ongoing BCG shortage in the U.S., discussing its impact on both treatment...
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