- Details
- Sam Chang hosts Yohann Loriot to discuss the LEAP-011 study. The study aims to evaluate the combination of pembrolizumab and lenvatinib for treating metastatic urothelial carcinoma in patients ineligible for cisplatin-based chemotherapy. Despite promising preliminary data from the KEYNOTE-146 study, the LEAP-011 trial finds no significant difference in progression-free survival (PFS) or overall su...
|
- Details
- Ashish Kamat hosts Guru Sonpavde to discuss key findings from the GU ASCO symposium. Dr. Sonpavde reviews a range of groundbreaking studies, emphasizing the potential of systemic therapy for metastatic bladder cancer. Noteworthy trials include TROPHY-U-01, which shows a 34% response rate combining sacituzumab govitecan with pembrolizumab, and a study on neoadjuvant enfortumab vedotin revealing a 3...
|
- Details
- Alicia Morgans talks with Petros Grivas about the TROPHY-U-01 study, which evaluates the efficacy of combining Sacituzumab govitecan (SG) with anti-PD-1 pembrolizumab in patients with platinum-refractory advanced urothelial cancer. Dr. Grivas elaborates on the study's rationale, citing SG's FDA approval based on a 27% response rate and tolerability. The study aims to explore the potential benefits...
|
- Details
- Dimitrios Makrakis joins Alicia Morgans and Petros Grivas in a discussion on a BJU International publication titled The Association of prior local therapy and outcomes with PD(L)1 inhibitor in advanced urothelial cancer looking at a data set trying to understand the important potential interaction between exposure to checkpoint inhibitors and local therapy for patients at the time of diagnosis ass...
|
- Details
- Alicia Morgans is joined by Elizabeth Plimack to discuss the importance of the Bladder Cancer Advocacy Network's (BCAN) Young Investigator Award Program. BCAN is the Bladder Cancer Advocacy Network which started as a small group of urology-based advocates and has grown to "the" organization for bladder cancer advocacy. The Young Investigator Award program strives to grow the science in bladder can...
|
- Details
- In this 2021 LUGPA presentation, Noah Hahn presents " Biomarkers and Next-Generation Sequencing in Advanced Bladder Cancer Patients" . Dr. Hahn discusses the differences in prognostic biomarkers and predictive biomarkers before discussing PD-L1 on the immunohistochemistry side, sequencing biomarkers, tumor mutational burden, and microsatellite instability or mismatch repair deficient tumors. Biogr...
|
- Details
- In this conversation with Alicia Morgans, Matthew Galsky highlights an exploratory analysis within the IMvigor130 randomized phase III study of patients with metastatic urothelial cancer who were treatment-naive. IMvigor130 was asking two separate questions, should we combine platinum-based chemotherapy with atezolizumab versus giving platinum-based chemotherapy alone, and should we give immune ch...
|
- Details
- In this UroToday discussion between Petros Grivas, MD, PhD, Guru Sonpavde, MD, and Maria Carlo, MD, the trio discuss recent publications on germline testing and genetic profiling. The conversation kicks off with a background on Dr. Carlo’s recent work concerning genetic testing for urothelial and bladder cancer patients. The conversation shifts to hear from Dr. Sonpavde about his recent work in lo...
|
- Details
- In this UroToday GU Oncology Journal Club, Christopher Wallis and Zachary Klaassen highlight a Journal of Clinical Oncology publication on a phase two open-label study of sacituzumab govitecan in patients with metastatic urothelial carcinoma, progressing after platinum-based chemotherapy and checkpoint inhibitors. TROPHY-U-01: A Phase II Open-Label Study of Sacituzumab Govitecan in Patients With M...
|
- Details
- In this UroToday discussion between Alicia Morgans and Samuel Funt, they discuss Samuel Funt’s recent phase 2 trial evaluating the use of atezolizumab, with gemcitabine and cisplatin, as neoadjuvant therapy for muscle-invasive bladder cancer (MIBC). The conversation begins with background on the study, beginning with Dr. Funt’s description of neoadjuvant cisplatin-based chemotherapy as the standar...
|
