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- Bellmunt Risk Score, based on Eastern Cooperative Oncology Group (ECOG) performance status (PS), hemoglobin levels and presence of liver metastases, is the most established prognostic algorithm for patients with advanced urothelial cancer (aUC) progressing after platinum-based chemotherapy. Existing algorithms may not be sufficient following the introduction of immunotherapy. Our aim was to develo...
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- Petros Grivas elaborates on the structure, work, and initiatives of the ECOG-ACRIN Cooperative Group, emphasizing its diverse committees and its collaboration with the NCI. He highlights the Group's exploration of targeted therapies and non-immunotherapy combinations, especially through their innovative ComboMATCH program, designed to overcome resistance to single-agent targeted therapies. Grivas...
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- In this conversation, Sam Chang discusses a publication with Mark Tyson that focuses on the use of the TAR-200 device in patients with muscle-invasive bladder cancer. The study aimed to understand the safety, tolerability, and preliminary efficacy of the device in patients who were not suitable for radical cystectomy or radiation therapy. The initial findings showed that the device was well-tolera...
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- In this discussion, Zach Klaassen and Sarah Psutka focus on muscle-invasive bladder cancer and the challenges faced by high-risk patients undergoing radical cystectomy. They discuss the complexities of the surgery, including the reconstructive and bowel components, as well as the comorbidities and frailty commonly observed in bladder cancer patients. The importance of evaluating social support and...
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- In this conversation, Ashish Kamat welcomes Andrea Necchi to present his research on the Vesical Imaging-Reporting and Data System (VI-RADS) and its correlation with the pathologic and molecular outcomes of patients undergoing perioperative IO therapy in the context of the PURE-01 study. The study focuses on the evaluation of MRI data and the response to neoadjuvant Pembrolizumab in muscle-invasiv...
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- In this conversation hosted by Ashish Kamat, Professors Param Mariappan and Maria Carmen Mir debate the pros and cons of organ-sparing cystectomy in bladder cancer patients. Professor Param Mariappan opposed the motion of organ preservation, highlighting the challenges and complexities associated with preserving reproductive organs for continence and sexual function. He discussed the limitations o...
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- Matt Galsky joins Sam Chang in a conversation about the long-term results of the IMvigor130 randomized phase III study which evaluated the use of atezolizumab in combination with platinum/gemcitabine chemotherapy versus platinum/gemcitabine chemotherapy alone in patients with metastatic urothelial carcinoma. The study used a hierarchical statistical analysis plan, and the first analysis showed a s...
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- Jason Brown joins Sam Chang in conversation on the results of neoadjuvant combination therapy prior to cystectomy and nephroureterectomy. This is a multi-institutional phase Ib/II two-stage study investigating chemo-immunotherapy in patients with cisplatin-eligible or ineligible muscle-invasive urothelial carcinoma. The treatment for cisplatin-eligible patients included gemcitabine, cisplatin, and...
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- Matthew Galsky and Alicia Morgans discuss the co-primary endpoint analysis of HCRN GU 16-257, a phase II clinical trial investigating the efficacy of gemcitabine, cisplatin, and nivolumab in patients with muscle-invasive bladder cancer who are undergoing selective bladder-sparing treatment. The trial investigated whether a subset of patients could be treated with systemic therapy and avoid definit...
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- Tanya Jindal and Vadim Koshkin join Petros Grivas to discuss their work to help identify potential biomarkers of response to enfortumab vedotin (EV) in patients with advanced urothelial carcinoma using a patient cohort in the UNITE dataset. The UNITE study researchers analyzed biomarkers associated with enfortumab vedotin (EV) treatment outcomes in patients with advanced urothelial carcinoma. They...
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