OBJECTIVES: The aim of this study was to evaluate the prognostic significance of the ureteral location of the upper tract urinary carcinoma (UTUC).
PATIENTS AND METHODS: Between January 1998 and December 2007, 161 patients with UTUC were operated in our center. Tumors were located on renal pelvis in 51% of cases, on the ureter in 34% of cases and in both locations in 15% of cases. Nephroureterectomy was performed in 79.5% of cases (128/161) whereas a conservative treatment was performed in 20.5% of cases (33/161).
RESULTS: In our series, 29.8% of patients had primary bladder cancer and 14.3% had synchronous bladder tumor. At a median follow-up of 42.5 months, 38.6% of patients developed bladder recurrence and 4.8% developed controlateral upper tract tumor. In multivariate analysis, ureteral location and existence of synchronous bladder tumor were independent prognostic factors of bladder recurrence (P=0.009 and P=0.025, respectively). Multivariate analysis retained T-stage and ureteral location as independent prognostic factors in both overall and disease-free survival (P=0.002 and P=0.0008 respectively for ureteral location).
CONCLUSION: Ureteral location was an independent prognostic factor of bladder recurrence and was associated with a poorer prognosis.
Written by:
Le Goux C, Pignot G, Amsellem-Ouazana D, Vieillefond A, Peyromaure M, Flam T, Debré B, Zerbib M. Are you the author?
Service d'urologie, hôpital Cochin, université Paris-V - Paris Descartes, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
Reference: Prog Urol. 2013 May;23(6):399-404.
doi: 10.1016/j.purol.2013.01.025
PubMed Abstract
PMID: 23628098
Article in French.
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