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Upper Tract Tumors

Risk factors of renal function deterioration after radical nephroureterectomy for upper tract urothelial carcinoma.

To investigate the risk factors of renal function deterioration after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC).

A total of 153 patients with UTUC who underwent radical surgery at a high-volume center in China from January 2015 to December 2019 were included in this study.

Upper tract urothelial cancer (UTUC) genomic profiling and correlation regarding benefit of platinum-based chemotherapy.

Upper tract urothelial cancer (UTUC) are rare subsets of urothelial cancer, which typically present with more aggressive course. Molecular markers stratifying urothelial tumors as luminal subtype and non-luminal subtype tumors have been proposed to select patients who may have greater or lesser benefit from neoadjuvant systemic therapy in bladder cancer, though not yet evaluated in UTUC.

Analysis of Neoadjuvant Chemotherapy Utilization, Pathologic Response, and Overall Survival in Upper Tract Urothelial Carcinoma.

Upper tract urothelial carcinoma (UTUC) is a rare malignancy with poor prognosis. Radical nephroureterectomy (RNU) remains the standard treatment for high-risk UTUC. Considering the decline in renal function with RNU and results from prospective trials, NAC has emerged as a favored perioperative treatment for chemo-eligible patients with UTUC.

The biologic landscape and therapeutic implications of upper tract urothelial cancer.

Management of upper tract urothelial cancer (UTUC) has been largely extrapolated from bladder cancer due to its rarity; however, unique biological and clinical differences between UTUC and bladder cancer have been uncovered.

Outcomes of laparoscopic, robotic and open nephroureterectomy with bladder cuff excision in patients with T3T4 upper urinary tract urothelial carcinoma: a multi-center retrospective study.

Nephroureterectomy with bladder cuff excision is the standard treatment for high-risk upper urinary tract urothelial carcinoma (UTUC). The role of minimally invasive surgery in treating locally advanced UTUC remains controversial.

Survival impact of variant histology in patients with upper tract urothelial carcinoma after radical nephroureterectomy.

To investigate the prognostic impact of variant histology (VH) on survival outcomes in upper tract urothelial carcinoma (UTUC) patients after radical nephroureterectomy (RNU).

Data from 635 UTUC patients who underwent RNU at our institution from May 2003 to June 2019 were retrospectively acquired and analyzed.

Survival Outcomes Across Surgical Approaches in Octogenarians with UTUC - Expert Commentary

Upper tract urothelial carcinoma (UTUC) represents 5% of urothelial cancers, yet it can be highly aggressive and associated with poor prognosis. The standard of care is radical nephroureterectomy (RNU) with bladder cuff resection and perioperative chemotherapy. However, surgery carries risks and complications, particularly in patients with comorbidities. Advances in recent years have allowed some patients to receive nephron-sparing surgery, but this requires careful consideration of potential risk versus benefit of a conservative approach. Wang et al. aimed to investigate the impact of different surgical approaches on outcomes among octogenarians with UTUC.

Role of neoadjuvant chemotherapy in patients with locally advanced and clinically positive nodes Upper Tract Urothelial Carcinoma treated with Nephroureterectomy: real-world data from the ROBUUST 2.0 Registry.

To assess the impact of neoadjuvant and adjuvant chemotherapy on survival outcomes, within a large multicenter cohort of Upper tract urothelial carcinoma patients treated with Nephroureterectomy.

A multicenter retrospective analysis utilizing the Robotic surgery for Upper Tract Urothelial Cancer Study registry was performed.

Clinical Implications of the Molecular and Genomic Landscape of Upper Tract Urothelial Carcinoma.

Upper tract urothelial carcinoma (UTUC) is an aggressive entity with treatment strategies mirroring bladder cancer. Genomic and molecular profiling allows for a better characterization of this disease and allows for patient-tailored approaches.

If Not Now, Then When? The Need for New Evidence in the Robotic Management of Upper Tract Urothelial Carcinoma - Beyond the Abstract

The current manuscript presented an overview of the existing challenges in robotic nephroureterectomy (RNU) for the treatment of upper tract urothelial carcinoma (UTUC) and outlined a multicentric research project aimed at filling knowledge gaps in this area. The study was led by the Junior ERUS- EAU/YAU Working Group on Robot-assisted Surgery.
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