PURPOSE: Although smoking status has a significant association with clinical features in patients with bladder cancer, there have been few reports on the impact of smoking on clinical outcome of upper tract urothelial cancer (UTUC).
The aim of the present study was to investigate the possible influence of smoking status on subsequent bladder recurrence after radical nephroureterectomy (RNU).
MATERIALS AND METHODS: We identified a study population of 245 consecutive patients treated surgically for UTUC at our 3 institutions between 1994 and 2010. The associations between the subsequent bladder recurrence and the clinicopathological parameters of a patient including the smoking status were analyzed.
RESULTS: The 3-year bladder recurrence-free survival rates were 32.6% in current smokers, 37.6% in ex-smokers and 61.7% in non-smokers. Multivariate analysis showed that male gender (P =0.013, HR=1.90 (1.15-3.16)) and smoking status (ex-smokers; P =0.027, HR=1.77 (1.07-2.93), current smokers; P =0.035, HR=1.58 (1.03-2.42)) were independent risk factors for subsequent bladder recurrence. In addition, we focused on patients with positive smoking history: patients with a number of pack-years ≥50 showed significantly higher incidence of subsequent bladder recurrence following RNU (P =0.003, HR=2.00).
CONCLUSIONS: Positive smoking history and male gender were independent risk factors for subsequent bladder recurrence following RNU, and a larger number of cigarettes smoked may increase the incidence of bladder recurrence in patients with UTUC.
Written by:
Hagiwara M, Kikuchi E, Tanaka N, Matsumoto K, Ide H, Miyajima A, Masuda T, Nakamura S, Oya M. Are you the author?
Department of Urology, Keio University School of Medicine, Tokyo, Japan.
Reference: J Urol. 2013 Jan 14. pii: S0022-5347(13)00053-0.
doi: 10.1016/j.juro.2013.01.024
PubMed Abstract
PMID: 23328579
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