- Details
- Justin Drake, University of Minnesota, discusses the latest and ongoing research associated with the correlation between RET gene expression and neuroendocrine prostate cancer. The recent data shows enhanced RET gene expression in patients that have this AR negative neuroendocrine positive phenotype. Drake also highlighted his work in the development of noninvasive ways of detecting RET signaling...
|
- Details
- Tom Keane discusses a presentation by Laurence Klotz given at the 2019 Société Internationale d'Urologie meeting on the topic of recent developments in imaging prior to a prostate biopsy. Dr. Klotz reviewed several studies comparing MRI to transrectal biopsies' effectiveness in detecting and ruling out clinically significant cancer. He also reviewed the PRECISION trial, which compared systemic bio...
|
- Details
- In this episode of Kidney Cancer Today, Monty Pal and Jamie Landman team up with Laura Bukavina and Lee Ponsky to discuss consults for benign renal cysts undergoing unnecessary active surveillance. Among other topics, their conversation especially touches on present flaws in the healthcare system, including the appropriate evaluation of renal cysts and healthcare disparities in accessibility to ac...
|
- Details
- Phuoc Tran, Johns Hopkins University, provides an overview of several ongoing clinical trials for prostate cancer. SALV-ENZA is a Phase II randomized placebo-controlled trial of salvage radiation, which then randomizes to either to placebo or the oral next-generation antiandrogen drug known as enzalutamide. Dr. Tran also reviews the ORIOLE and RAVENS clinical trials which examine metastasis-direct...
|
- Details
- Kevin McVary discusses the emerging field of minimally invasive surgical therapies (MIST) for the treatment of lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH). More men are seeking treatment for LUTS/BPH however the number of men choosing a more invasive surgical option is decreasing. Medications have side effects leading to non-compliance by patients in as little as a few m...
|
- Details
- Neal Shore and Bertrand Tombal discuss the importance of bone health agents, particularly in patients receiving castrate-resistant prostate cancer agents. Highlights of their conversation include the use of antiresorptive therapy to reduce the risk of skeletal-related events in men with bone mCRPC and decreased fracture rate by mandating bone-protecting agents in the EORTC 1333/PEACE III trial. Bi...
|
- Details
- Panagiotis Vlachostergios, MD, Ph.D., describes a study that he conducted reviewing the outcomes of patients who participated in PSMA targeted radionuclide trials over the past 18 years. Dr. Vlachostergios generated a visual score of PSMA expression to determine an association with response to PSMA-radio-nucleotide targeted therapies. Higher PSMA expressers showed an association with PSA response....
|
- Details
- Darren Feldman, MD, and Alicia Morgans, MD, MPH, discuss the nuances of treating non-clear cell kidney cancer, a disease that has historically been underrepresented in phase 3 clinical trials of kidney cancer and is also histologically heterogeneous. This heterogeneity makes variations of the disease rare, and thus single-agent VEGF Tyrosine Kinase Inhibitors (TKIs) aren't always effective. Dr. Fe...
|
- Details
- Che-Kai Tsao, MD, and Alicia Morgans, MD, MPH, sit down to discuss emerging therapeutic options for kidney cancer, specifically focused on patient groups that haven’t historically qualified for targeted treatments. Dr. Tsao highlights a new wealth of treatment options, honing in on checkpoint inhibitors for metastatic kidney cancer — specifically clear cell — and reviewing ongoing and accruing tri...
|
- Details
- Wassim Abida, MD, describes his work to facilitate both better understanding of the genomic landscape of prostate cancer while simultaneously integrating new genomic information into clinical practice. In a conversation with Alicia Morgans, MD, MPH, Dr. Abida describes how to identify the subsets of patients that serve to benefit from targeted therapies, referencing the use of pembrolizumab for MS...
|
