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- Bishoy Faltas and Charles Ryan discuss some of Bishoy's work using cell-free DNA, or circulating tumor DNA, and what it means in urothelial cancer today. Circulating tumor DNA is DNA that's shed by the tumor into the bloodstream, and the advantage of the current technology and the evolving technology is that we can actually get that DNA. In this work being discussed Bishoy and colleagues are focus...
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- Professor Matt Galsky joins Alicia Morgans to share details of an analysis looking at FGFR mutations in patients who have received checkpoint inhibitor therapy on clinical trials. In this study, Matt Galsky and colleagues examined the impact of a mutated gene found in a subset of urothelial cancers on response to treatment with immunotherapy. Using data derived from two clinical trials exploring C...
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- Alicia Morgans and Petros Grivas discuss the use of antibody-drug conjugates (ADC) as a new approach for the treatment of metastatic urothelial carcinoma (mUC). The two review the latest data presented at the 2019 American Society of Clinical Oncology meeting, specifically the use of enfortumab vedotin. Dr. Grivas further discusses sacituzumab govitecan, another popular ADC, and the promising clin...
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- Petros Grivas and Alicia Morgans join in a conversation about the recently FDA accelerated approval of erdafitinib in metastatic bladder cancer for tumors that exhibit mutations active isoforms of FGFR 2 and FGFR 3. Dr. Grivas discusses the companion biomarkers used in the determination of genomic sequencing of the tumor tissue exhibiting FGF reception mutations. The indication for erdafitinib (pa...
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- Ali Khaki joins Petros Grivas in a discussion on the performance status and response to immune checkpoint inhibition in patients with advanced urothelial cancer. These checkpoint inhibitors have changed the landscape of treatment for urothelial cancer and there has been more and more interest in using them in people who are not suitable for chemotherapy, as approved in the post-platinum setting, a...
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- Monty Pal and Petros Grivas discuss new approaches being taken in the neoadjuvant disease setting for bladder cancer. Petros highlights the urgent unmet need for novel therapies for bladder cancer that immunotherapy is trying to meet through innovative clinical trials. He references two clinical phase II trials, the PURE-01 by Dr. Necchi and colleagues, pembrolizumab in Cisplatin-fit patients, and...
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- Brenda Martone discusses the nurse practitioner's role in assessing and managing immune related complications and toxicities associated with checkpoint inhibitors with Alicia Morgans. Brenda notes that immune related reactions may occur months after a single dose of the immune checkpoint inhibitors pembrolizumab, atezolizumab, and durvalumab. Immune-related reactions may include diarrhea and colit...
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- FGFR alterations and specifically ones involving the third and the second isotype of the receptor, FGFR3 and FGFR2, are activated and present in between 15 to 20%, possibly higher, of patients with locally advanced and metastatic bladder cancer. We know that these are genetic drivers and the therapeutic targeting of this pathway can lead to responses. Patients should be selected for therapy based...
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- Petros Grivas, MD Ph.D. and Alicia Morgans discuss the rapidly changing landscape in the treatment of advanced urothelial cancer. Dr. Grivas discusses the era of immunotherapy in advanced bladder cancer and the development of new drugs, new combinations, and biomarkers. Biographies: Petros Grivas, MD, Ph.D. is an Associate Professor and the Clinical Director of the Genitourinary Cancers Program at...
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- Andrea Necchi and Alicia Morgans discuss the evolution of neoadjuvant treatment for muscle-invasive bladder cancer (MIBC) including the role of immunotherapy and chemotherapy prior to radical surgery. They discuss the PURE-01study which included all-comers regardless of cisplatin eligibility. The early data from PURE-01 with neoadjuvant pembrolizumab demonstrated a 42% pathological complete respon...
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