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- Alicia Morgans hosts Guru Sonpavde and Bradley McGregor to discuss the DAD trial, which uniquely combines enfortumab vedotin and sacituzumab govitecan, two antibody drug conjugates (ADCs), for advanced urothelial carcinoma. Dr. Sonpavde highlights the distinct mechanisms and non-overlapping toxicities of these drugs. Funded by Gilead, the trial adopts a Phase I BOIN design, starting with lower dos...
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- Ashish Kamat and Petros Grivas discuss recent advancements in metastatic bladder cancer treatments from ESMO Congress 2023. Key highlights include the CheckMate-901 and EV-302 trials. Dr. Grivas highlights the CheckMate-901 trial's success with the combination of gemcitabine, cisplatin, and nivolumab, which shows notable improvements in overall survival and progression-free survival with a managea...
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- Alicia Morgans speaks with Cora Sternberg about the EV-302 study presented at ESMO 2023. This study marks a significant shift in treating advanced metastatic urothelial cancer, traditionally managed with cisplatin or carboplatin-based chemotherapy. EV-302 introduces a combination of enfortumab vedotin (EV), an antibody-drug conjugate targeting Nectin-4, and pembrolizumab, an anti-PD-1 inhibitor im...
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- Shilpa Gupta shares significant insights on the EV-103 study focused on the four-year outcomes of enfortumab vedotin (EV) and pembrolizumab as a frontline treatment for locally advanced or metastatic urothelial cancer patients who are cisplatin ineligible. Dr. Gupta discusses the 73% response rates, median overall survival exceeding two years, and over 41% of patients remaining progression-free af...
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- Rafee Talukder discusses his presentation on his research into the effects of MTAP loss on survival rates among advanced urothelial cancer patients undergoing immunotherapy. With the help of an extensive international database, his team found that patients with this MTAP loss exhibited worse observed response rates and a trend toward poorer progression-free survival. In addition, the conversation...
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- Alicia Morgans speaks with Jonathan Rosenberg about the approval of the combination of Enfortumab vedotin (EV) and Pembrolizumab for urothelial carcinoma treatment. Dr. Rosenberg notes the impressive response rates (64.5%) from the combination, as compared to EV monotherapy (45%), and highlights the promising survival rates, which significantly exceed expectations for a cisplatin-eligible populati...
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- Petros Grivas elaborates on the structure, work, and initiatives of the ECOG-ACRIN Cooperative Group, emphasizing its diverse committees and its collaboration with the NCI. He highlights the Group's exploration of targeted therapies and non-immunotherapy combinations, especially through their innovative ComboMATCH program, designed to overcome resistance to single-agent targeted therapies. Grivas...
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- Tanya Jindal and Vadim Koshkin join Petros Grivas to discuss their work to help identify potential biomarkers of response to enfortumab vedotin (EV) in patients with advanced urothelial carcinoma using a patient cohort in the UNITE dataset. The UNITE study researchers analyzed biomarkers associated with enfortumab vedotin (EV) treatment outcomes in patients with advanced urothelial carcinoma. They...
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- Matt Galsky joins Sam Chang in a conversation about the long-term results of CheckMate 274, a randomized phase III study that enrolled patients with muscle-invasive urothelial cancer at high risk for recurrence after radical surgery. Patients were randomized to receive adjuvant nivolumab or placebo, with adjuvant nivolumab given for up to a year. The study's co-primary endpoints were disease-free...
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- Srikala Sridhar joins Sam Chang in discussing long-term follow-up from the JAVELIN Bladder 100 trial of avelumab first-line maintenance for advanced urothelial carcinoma. The JAVELIN-100 study was conducted on patients with metastatic urothelial carcinoma who had received frontline platinum-based chemotherapy and achieved a disease response. These patients were then randomized to receive either av...
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