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- Zachary Klaassen is joined by Rashid Sayyid to present a case-based discussion on the management of low-grade upper tract urothelial carcinoma. They focus on a 68-year-old female patient, detailing her medical history, symptoms, and diagnostic workup, including CT urogram, according to the American Urological Association (AUA) guidelines. They explore various considerations such as standardized re...
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- Sam Chang and Sarah Psutka discuss the importance of personalized prescriptions and rehabilitation in urologic oncology, with an emphasis on frailty evaluation and prehabilitation. Dr. Psutka urges the shift from subjective preoperative risk to objective measures for better treatment outcomes, using Comprehensive Geriatric Assessments (CGA) and anatomic assessments, while highlighting the correlat...
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- Sam Chang interviews Jonathan Coleman and Wesley Yip. They delve into a Journal of Urology article detailing promising advancements in treating upper tract disease using photodynamic therapy, a non-invasive treatment method developed by Drs. Coleman and Yip. Their study seeks to decrease over-treatment of the disease, which often results in unnecessary kidney removal. Preliminary results show 50%...
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- In a cross-institutional study investigating the impact of nephroureterectomy on renal function, urologist Clara Cerrato and her international team analyzed data from 576 patients across 17 tertiary centers. They discovered factors such as age, hydronephrosis, and postoperative day one acute kidney injury were independently associated with the estimated glomerular filtration rate (eGFR) variation....
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- In this discussion, Sam Chang hosts Amy Luckenbaugh, who shares her experience establishing a new treatment program for patients with low-grade upper tract urothelial carcinoma at Vanderbilt, using a novel agent called JELMYTO® (mitomycin). This reverse thermal hydrogel is administered either retrograde or antegrade and has shown encouraging outcomes, with a complete response rate of 58%. Luckenba...
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- Sam Chang speaks with Jeannie Hoffman-Censits about the AUA guidelines on upper tract urothelial carcinoma. They discussed how multidisciplinary panels are important in creating such guidelines and the variability in the treatment of patients with upper tract disease. Dr. Hoffman-Censits mentioned the need for more streamlined and consistent guideline-based approaches to these patients to ensure t...
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- Jonathan Coleman, chair of the AUA guidelines for upper tract urothelial carcinoma, joins Sam Chang in discussing the process of putting together these guidelines, including the use of biostatisticians to collect data from retrospective and prospective studies. The guidelines aim to provide a standardized process for evaluating, diagnosing, and risk-stratifying patients with upper tract urothelial...
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- Sam Chang led a group discussion highlighting a panel presentation on management evaluation, surveillance, and follow-up individuals with upper tract urothelial carcinoma, a presentation that took place at the AUA 2023. Surena Matin, Jay Raman, Sima Porten, and Tomonori Habuch join in a discussion on topics including lymphadenectomy for upper tract urothelial cancer, risk stratification, sequencin...
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- Andrea Gallioli and Angelo Territo join Sam Chang in a discussion on using DNA methylation markers to diagnose upper tract urothelial carcinoma in a single center prospective clinical trial. They evaluated the accuracy of a urine biomarker test called Bladder EpiCheck and compared it with urinary cytology. EpiCheck outperformed cytology in any aspect, with a higher sensitivity and negative predict...
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- Sam Chang and Karan Jatwani discuss a study looking at the impact of neoadjuvant or adjuvant chemotherapy for patients with invasive disease, T2 disease, and the role of nephroureterectomy and how these treatments may impact findings. The study analyzed the NCDB database from 2004 to 2018 and found that neoadjuvant chemotherapy use was associated with a significantly improved overall survival haza...
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