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- Zach Klaassen speaks with Abhishek Srivastava about the significance of germline and genomic testing in advanced prostate cancer. Dr. Srivastava elaborates on his recent publication, which aims to improve the penetration of such testing in urology, particularly in community practices. He emphasizes the importance of cascade testing for identifying actionable mutations and influencing treatment opt...
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- Tamara Jamaspishvili delves into her group's study on PTEN loss as an early predictor of prostate cancer metastasis post-surgery. The study employs artificial intelligence to enhance the accuracy of PTEN loss assessment, traditionally done manually by pathologists. Dr. Jamaspishvili explains that PTEN, a tumor suppressor gene, is a critical biomarker for aggressive prostate cancer. Her team's AI-b...
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- In this conversation, Zach Klaassen speaks with Alberto Martini about his study published in the Journal of Urology. The study focuses on the feasibility of unilateral pelvic lymph node dissection in prostate cancer patients, particularly in the era of multiparametric MRI and targeted biopsy. Dr. Martini shares that the study was motivated by the need to improve the specificity of current models u...
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- In this discussion, Zach Klaassen is joined by Daniel Dickstein to discuss a groundbreaking publication in Nature Reviews Urology, which focuses on sexual health and treatment-related sexual dysfunction in sexual and gender minorities with prostate cancer. Dr. Dickstein shares the inspiration behind the study, emphasizing the lack of information on how treatments impact sexual and gender minoritie...
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- In this conversation, Andrea Miyahira hosts Gerhardt Attard to discuss a publication in Nature Communications, specifically focusing on the genomic architecture of lethal prostate cancer clones. The study from Dr. Attard’s team examines alterations in the androgen receptor (AR) and their association with resistance to treatments like abiraterone and enzalutamide. Dr. Attard highlights the intrapat...
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- Scarlett Lin Gomez discusses the RESPOND study, which aims to understand the disproportionate impact of prostate cancer on African-American men. Dr. Gomez outlines the study's multi-level, socio-ecological approach, which integrates factors from structural racism and healthcare access to tumor biology. Funded by the NCI and the Prostate Cancer Foundation, the study has successfully recruited over...
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- Nima Sharifi presents a published paper that investigates the role of testosterone in prostate cancer. Over a decade-long study, Dr. Sharifi's team discovered that a subset of men undergoing radical prostatectomy have unusually high levels of periprostatic testosterone, linked to worse clinical outcomes such as PSA recurrence or salvage radiation therapy. This surprising finding challenges convent...
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- Daniela Brina discusses her team’s paper on prostate cancer pathways and the role of myeloid-derived suppressor cells (MDSCs) in tumor progression. The study delves into the extracellular interaction between prostate cancer and MDSCs, employing polysome profiling techniques across different genetic backgrounds. Dr. Brina and her team identified specific ligands and receptors that facilitate the re...
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- In this interview, Monica Chatwal talks with Alicia Morgans about her publication "Fear of Saying No: Setting Boundaries with our Patients and Ourselves," in the ASCO Education Book for 2023. Dr. Chatwal, together with the ASCO Ethics Committee, emphasizes the growing need for personal boundaries within the rapidly changing landscape of healthcare and oncology. The article explores the balance bet...
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- Andrea Miyahira hosts a discussion with Karen Sfanos about her group's research on Proliferative Inflammatory Atrophy (PIA) of the prostate, published in the Journal of Pathology. The paper, titled "Club-Like Cells in Proliferative Inflammatory Atrophy of the Prostate," investigates the relationship between PIA and prostate cancer, focusing on the abnormal proliferation of PIA cells resembling lun...
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