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- Piet Ost discusses the treatment of oligorecurrent prostate cancer after local therapy at the Advanced Prostate Cancer Consensus Conference (APCCC 2019). Currently, there is no consensus definition for oligometastatic disease although a consensus working definition is being developed by the EORTC-ESTRO group. Highlighting findings from his own trial, Dr. Ost also frames these two main points durin...
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- Michael Morris presented de novo oligometastatic prostate cancer at the Advanced Prostate Cancer Consensus Conference (APCCC 2019) during the session on PSA Recurrence After Radical Local Therapy and Oligometastatic Prostate Cancer. His presentation highlights trials that support level 1 evidence that AR-directed therapy improves overall survival in M1 disease, trials that have assessed metastasis...
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- Charles Drake presented on immunotherapy for metastatic castration-resistant prostate cancer (mCRPC) during the Management of Castration-resistant Prostate Cancer (CRPC) session at the Advanced Prostate Cancer Consensus Conference (APCCC) 2019. He reviews several immunotherapy trials including the first major successful trial in immunotherapy for prostate cancer, the IMPACT trial in 2010 which led...
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- Fernando Maluf joins Charles Ryan to discuss the data from the first Prostate Cancer Global Consensus Conference for Developing Countries. This was a tremendous achievement in which more than a hundred physicians from all over the world, particularly from developing countries in Latin America, Africa, and the Middle East participated. Physicians that participated included several specialties: urol...
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- Alicia Morgans and Brad McGregor discuss rare genitourinary histologies and the efforts to find treatment options for populations not always included in clinical trials. Most clinical trials are developed and designed for the most common subtypes, not including atypical variant histologies often found in bladder and prostate cancers. Given the tumor agnostic approach of immunotherapy, Brad and his...
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- Thomas Steuber spoke on the role of surgery in the setting of metastatic prostate cancer at the Advanced Prostate Cancer Consensus Conference (APCCC 2019). He highlights the advantages of surgical removal of the primary tumor, the effects of surgery on cancer-specific survival and overall survival compared with no local treatment in the setting of de novo metastatic prostate cancer, and prospectiv...
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- In this presentation by Fernando Maluf at the 2019 Advanced Prostate Cancer Consensus Conference (APCCC) he summarizes the results of the first Latin American Oncology Group (LACOG) consensus conference, a Cooperative Group Consensus that takes place in Brazil, a consensus conference for developing countries. This unique conference provided guidelines for prostate cancer, specifically for areas of...
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- David Wise discusses his work studying the role of DKK1 as a driver of some forms of CRPC with Charles Ryan. He describes that the role of immune checkpoint inhibitors in prostate cancer has been largely disappointing. Dr. Wise shares his previous findings that DKK1 is upregulated in a subset of metastatic CRPC with low or no expression of AR and that do not have features of neuroendocrine or smal...
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- Susan Halabi provides an update on an externally validated prognostic model of overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC) treated with docetaxel, which included eight important prognostic factors variables of overall survival: opioid analgesic use, ECOG performance status, albumin, disease site, LDH, hemoglobin, PSA, and alkaline phosphatase. They use...
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- Oliver Sartor joins Charles Ryan in a discussion on a Phase 4 registry trial in men with metastatic castration-resistant prostate cancer (mCRPC). The IMPACT study analyses suggested that overall survival (OS) was longer in treated and control patients with low baseline PSA, and OS benefit was greatest for sipuleucel-T versus control in the patients with the lowest PSA (Schellhammer Urol 2013). Eli...
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