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- Ashish Kamat and Matthew Galsky discuss a phase 2 trial on organ sparing for muscle-invasive bladder cancer, published in Nature Medicine. Dr. Galsky highlights the trial's focus on systemic therapy as an alternative to cystectomy, noting its potential for curative outcomes. The study involved patients receiving gemcitabine-cisplatin plus nivolumab, followed by clinical restaging to identify clini...
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- Rashid Sayyid and Zach Klaassen discuss the Society for Immunotherapy of Cancer and the International Bladder Cancer Group's recommendations for clinical trial design in high-risk non-muscle-invasive bladder cancer. The consensus statement, led by Dr. Ashish Kamat and published in the Journal of Clinical Oncology, aims to guide investigators in late-phase clinical trial design. The panel, comprisi...
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- Ashish Kamat and Morgan Rouprêt explore advancements in non-muscle-invasive bladder cancer (NMIBC) treatments. Professor Rouprêt emphasizes two NMIBC categories: high-grade disease, where muscle-invasive and high-grade bladder cancer lines blur, and low-grade disease, where de-intensification of follow-up and treatment is sought. He highlights the THOR-2 cohort presented by Jim Catto at ESMO, show...
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- Zach Klaassen and Gautam (Tom) Jayram explore the use of blue light cystoscopy in bladder cancer. Dr. Jayram explains its mechanism, where an optical agent, interacting with the heme biosynthetic pathway, causes cancer cells to accumulate photo porphyrins that light up under specific wavelengths. This technology is crucial for patients suspected of having or with a history of bladder cancer, enhan...
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- Zach Klaassen and Rob Svatek explore the potential of cretostimogene, a novel medication for non-muscle invasive bladder cancer. Dr. Svatek describes cretostimogene as an oncolytic virus targeting cells with retinoblastoma pathway defects, common in cancer cells. This treatment, when instilled in the bladder, prompts immune cells to destroy cancer cells. Highlighted are several key trials: CORE-00...
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- Siamak Daneshmand hosts Trinity Bivalacqua to discuss advancements in non-muscle invasive bladder cancer, particularly focusing on newly FDA-approved therapies. Dr. Bivalacqua highlights the excitement surrounding the approval of new treatments for BCG unresponsive bladder cancer, including pembrolizumab and nadofaragene (ADSTILADRIN). He explains the significance of these developments, particular...
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- Tom Jayram hosts a panel of experts to discuss advancements in bladder cancer treatment, emphasizing personalized therapies, clinical trials, and the importance of a comprehensive approach. They highlight the role of nephron-sparing techniques and new tests in improving traditional diagnostic methods. Biographies: Tom Jayram, MD, Urology Associates P.C, Nashville, TN Daniel Saltzstein, MD, Urology...
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- Ashish Kamat and Petros Grivas discuss recent advancements in metastatic bladder cancer treatments from ESMO Congress 2023. Key highlights include the CheckMate-901 and EV-302 trials. Dr. Grivas highlights the CheckMate-901 trial's success with the combination of gemcitabine, cisplatin, and nivolumab, which shows notable improvements in overall survival and progression-free survival with a managea...
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- Ashish Kamat hosts Bente Jensen and Alex Filicevas to discuss key findings from a global survey on bladder cancer patient experiences and the supportive and complementary care needs of patients. This discussion is part of a four-part series in collaboration with UroToday and the World Bladder Cancer Patient Coalition. The World Bladder Cancer Patient Coalition serves as an international platform c...
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- Ashish Kamat is joined by Lori Cirefice and Lydia Makaroff who discuss the findings of the Global World Bladder Cancer Patient Coalition Survey, focusing on the impact of bladder cancer on daily life and caregivers. The survey, which garnered nearly 1,200 responses from 45 countries, reveals significant financial and emotional strain on patients and their carers. Key findings include that 50% of p...
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