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- (Length of conversation: 14 minutes) Alicia Morgans and Arjun Balar converse on the long-term efficacy data of atezolizumab in the 1st line setting as well as the 2nd line setting from the single-arm phase 2 trial. Discussion evolves to the recent safety alerts by the FDA highlighting the two studies, Keynote 361 and IMvigor 130. They question the applicability to clinical practice and the challen...
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- Medical oncologist, bladder cancer survivor, and author of Journey from Oncologist to Cancer Survivor and Patient Advocate in the Era of Precision Medicine, Burt Needles who was diagnosed with a rare form of bladder cancer, plasmacytoid variant in 2013, talks with Alicia Morgans about his unique perspective as a medical oncologist and clinician to a cancer survivor and patient advocate. Biographie...
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- (Length of Discussion: 11 min) Ashish Kamat, MD, MPH and Alicia Morgans, MD discuss non-muscle invasive bladder cancer, where the field stands particularly for BCG refractory patients and the definition of the BCG unresponsive patient. Ashish overviews the efforts of the SUO-CTC Bladder Committee and important updates and trials in this disease state . Biographies: Ashish M. Kamat, MD Alicia Morga...
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- Stephen Williams and Ashish Kamat discuss the paper, Impact of Psychiatric Illness on Decreased Survival in Elderly Patients with Bladder Cancer in the United States, a study which addresses problems that bladder cancer patients face and the difficulties they experience coping after major interventions for bladder cancer therapy. The conversation also includes recommendations on how to educate and...
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- (Length of Discussion: 16 min) Dr. Tom Keane discusses the rapidly changing landscape in advanced bladder cancer with the introduction of immune checkpoint inhibitors. To begin his discussion he references a presentation by Thomas Powles, MD from the 2018 ASCO GU meeting where Dr. Powles provided an overview of immune checkpoint inhibitors in urothelial carcinoma at the current time and Dr. Powles...
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- (Length of Discussion: 30 min) Petros Grivas and Alicia Morgans discuss the progress in systemic and immunotherapy in advanced bladder cancer. They discuss the biologic and immunologic background of urothelial cancer that paves the way for the development of potential biomarkers, as well as possible therapeutic targets in this disease. They share insights on the significant advances in systemic th...
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- Badrinath Konety and Alicia Morgans discuss biomarkers in bladder cancer. Concepts highlighted include incorporating clinical and other disease characteristics into biomarkers, so outcomes can be more accurately predicted. Biographies: Badrinath Konety, MD, MBA , is professor and chair at the University of Minnesota, where he holds the Dougherty Family Chair in Uro-Oncology and is Director of the...
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- (Length of Discussion: 20 min) There has been a limited number of new therapeutics, particularly in the area of patients who would benefit from advanced systemic bladder cancer treatments. Dr. Neal Shore reviews some pioneering work from the past such as MVAC and gemcitabine platinum based combinations but he notes those treatments are where things were left for many many years. The development of...
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- (Length of Discussion: 34 min) Dr. Thomas Guzzo starts his discussion by dialing back to 1997 to share with listeners the beginning of Enhanced Recovery After Surgery (ERAS) and the work of Dr. Kelhlet from Denmark who described multifactorial surgical stress responses such as the pathogenesis of postoperative sleep disturbances as multifactorial, and includes different neural stimulus (surgical s...
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- (Length of Discussion - 9 min) Dr. Alicia Morgans discusses with Dr. Guru Sonpavde the advances in the field of bladder cancer in regards to immunotherapy treatment approaches and recent ongoing clinical trials. Dr. Morgans refers to these treatment options and new studies as bringing a freshness to a desert like climate which has been bladder cancer treatment over the past several decades. Dr. So...
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