INTRODUCTION: Upper tract urinary carcinoma (UTUC) pT3 tumors are a heterogeneous entity including tumors invading the renal parenchyma, tumors with peripelvic fat invasion or peri-ureteral fat invasion.
The aim of this study was to evaluate the prognostic significance of these three different groups of pT3 tumors.
PATIENTS AND METHODS: Between 1998 and 2012, 205 patients with UTUC were operated in two centers, including 52 patients with pT3 tumor stage. pT3 tumors were divided into three groups: peri-ureteral fat invasion (pT3U, n=16), peripelvic fat invasion (pT3G, n=21), and renal parenchyma invasion (pT3P, n=15). The prognostic significance of the type of tumor infiltration was evaluated on specific and disease-free survival.
RESULTS: Median follow-up was 18.9 months [6-133.4]. In univariate analysis, renal parenchyma invasion was associated with a better prognostic in both specific (P=0.026) and disease-free survival (P=0.031) compared with peripelvic or peri-ureteral fat invasion. Mutivariate analysis retained the pT3 subgroup as an independant prognostic factor in both specific and disease-free survival (P=0.02).
CONCLUSION: pT3 tumors with renal parenchyma invasion had a better prognosis than those with peripelvic or peri-ureteral fat invasion. The heterogeneity of the pT3 group should be taken into account to improve the care of patients.
Written by:
Bruzzi M, Le Goux C, Pignot G, Amsellem-Ouazana D, Vieillefond A, Patard JJ, Zerbib M. Are you the author?
Service d'urologie, hôpital Bicêtre, université Paris-Sud Paris XI, 94270 Le Kremlin-Bicêtre, France; Service d'urologie, hôpital Cochin, université Paris Descartes Paris V, 75014 Paris, France; Service d'anatomopathologie, hôpital Cochin, 75014 Paris, France.
Reference: Prog Urol. 2014 Jul;24(9):556-62.
doi: 10.1016/j.purol.2013.12.005
PubMed Abstract
PMID: 24975790
Article in French.
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