To identify predictors and develop a score for overall survival of patients with intracerebral metastasis from testicular cancer.
Whole-brain radiation therapy program, age, Karnofsky performance score (KPS), number of intracerebral metastases, number of other metastatic sites and time between testicular cancer diagnosis and radiation therapy were analyzed for their association with overall survival in eight patients.
KPS of 80-90% was significantly associated with better overall survival (p=0.006), one or no other metastatic sites showed a trend for a better outcome (p=0.10). The following scores were assigned: KPS 60-70%=0 points, KPS 80-90%=1 point, ≥2 other metastatic sites=0 points, 0-1 other metastatic sites=1 point. Two groups, with 0 and with 1-2 points, were formed. Overall survival rates were 33% vs. 100% at 6 months and 0% vs. 100% at 12 months (p=0.006), respectively.
A simple instrument enabling physicians to judge the overall survival of patients with intracerebral metastasis from testicular cancer is provided.
Anticancer research. 2016 Sep [Epub]
Dirk Rades, Liesa Dziggel, Theo Veninga, Amira Bajrovic, Steven E Schild
Department of Radiation Oncology, University of Lubeck, Lubeck, Germany ., Department of Radiation Oncology, University of Lubeck, Lubeck, Germany., Department of Radiotherapy, Dr. Bernard Verbeeten Institute, Tilburg, the Netherlands., Department of Radiotherapy, University Medical Center Eppendorf, Hamburg, Germany., Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.