Almost all testicular germ cell tumours are proved to originate from carcinoma in situ cells.
Infertility is one of the factors that increase the risk of carcinoma in situ. The reported prevalence for carcinoma in situ from different parts of the world is 0-3.7% in infertile men. This retrospective study was performed to determine the prevalence of carcinoma in situ in Iranian infertile men. We reviewed the testicular biopsies of 1153 infertile men at the pathology department of Avicenna Infertility Center. One hundred and fifty-one cases were suspicious of having carcinoma in situ. Immunohistochemical marker for placental alkaline phosphatase was employed to confirm the diagnosis of carcinoma in situ. Positive results were detected in 7 (0.6%) of 1153 cases (95% CI 0.24%-1.24%), 6 (0.94%) of which (95% CI 0.34%-2.04%) were under the age of 35 years (636 patients were in this age group). This study is the first study in Iran determining the prevalence of carcinoma in situ among the infertile Iranian men; the result is in the range of reports from other countries.
Written by:
Soltanghoraee H, Pourkeramati F, Khoddami M, Amirjannati N, Akhondi MM, Soltani A. Are you the author?
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Reference: Andrologia. 2013 Jul 21. Epub ahead of print.
doi: 10.1111/and.12139
PubMed Abstract
PMID: 23869800
UroToday.com Testicular Cancer Section
