Cancer, a potentially fatal condition, is one of the leading causes of death worldwide. Among males aged 20 to 35, the most common cancer in healthy individuals is testicular cancer, accounting for 1% to 2% of all cancers in men.
Throughout this review, we have employed a targeted research approach, carefully handpicking the most representative and relevant articles on the subject. Our methodology involved a systematic review of the scientific literature to ensure a comprehensive and accurate overview of the available sources.
The onset and spread of testicular cancer are significantly influenced by genetic changes, including mutations in oncogenes, tu-mor suppressor genes, and DNA repair genes. As a result of identifying these specific genetic mutations in cancers, targeted medications have been developed to disrupt the signaling pathways affected by these genetic changes. To improve the diagnosis and treatment of this disease, it is crucial to understand its natural and clinical histories.
In order to comprehend cancer better and to discover new biomarkers and therapeutic targets, oncologists are increasingly employing omics methods, such as genomics, transcriptomics, proteomics, and metabolomics. Targeted medications that focus on specific genetic pathways and mutations hold promise for advancing the diagnosis and management of this disease.
La Clinica terapeutica. 2023 Dec [Epub]
G Madeo, G Bonetti, P E Maltese, B Tanzi, S Tezzele, C Mareso, F Agostini, D Generali, C A Donofrio, M Cominetti, A Fioravanti, L Riccio, T Beccari, M R Ceccarini, A E Calogero, R Cannarella, L Stuppia, L Stuppia, V Gatta, M Nughman, S Cecchin, G Marceddu, M Bertelli
MAGI'S LAB, Rovereto (TN), Italy., MAGI EUREGIO, Bolzano, Italy., Department of Medicine, Surgery and Health Sciences, University of Trieste, Italy; Multidisciplinary Unit of Breast Pathology and Translational Research, Cremona Hospital, Italy., Department of Neurosurgery, ASST Cremona, Italy., Department of Pharmaceutical Sciences, University of Perugia, Italy., Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy., Center for Advanced Studies and Technology, G. d'Annunzio University, Italy., Department of Psychological Health and Territorial Sciences, School of Medicine and Health Sciences, G. d'Annunzio University, Italy., Department of Biotechnology and Genetic Engineering, Kohat University of Science and Technology, Kohat Pakistan.