Testicular cancer (TCa) is a rare malignancy affecting young men worldwide. Sociodemographic factors, especially socioeconomic level (SEL) and healthcare access, seem to impact TCa incidence and outcomes, particularly among Hispanic populations. However, limited research has explored these variables in Hispanic groups. This study aimed to investigate sociodemographic and clinical factors in Mexico and their role in health disparities among Hispanic TCa patients. We retrospectively analyzed 244 Mexican TCa cases between 2007 and 2020 of a representative cohort with diverse social backgrounds from a national reference cancer center. Logistic regression identified risk factors for fatality: non-seminoma histology, advanced stage, and lower education levels. Age showed a significant trend as a risk factor. Patient delay and healthcare distance lacked significant associations. Inadequate treatment response and chemotherapy resistance were more likely in advanced stages, while higher education positively impacted treatment response. Cox regression highlighted non-seminoma histology, below-median SEL, higher education, and advanced-stage survival rates. Survival disparities emerged based on tumor histology and patient SEL. This research underscores the importance of comprehensive approaches that integrate sociodemographic, biological, and environmental factors to address health disparities improving outcomes through personalized interventions in Hispanic individuals with TCa.
Journal of racial and ethnic health disparities. 2023 Nov 14 [Epub ahead of print]
Juan Alberto Ríos-Rodríguez, Michel Montalvo-Casimiro, Diego Ivar Álvarez-López, Nancy Reynoso-Noverón, Berenice Cuevas-Estrada, Julia Mendoza-Pérez, Miguel A Jiménez-Ríos, Talia Wegman-Ostrosky, Pamela Salcedo-Tello, Anna Scavuzzo, Clementina Castro-Hernández, Luis A Herrera, Rodrigo González-Barrios
Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Mexico City, 14080, México., Unidad de Epidemiología en Cáncer, Instituto Nacional de Cancerología, Mexico City, 14080, México., Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Departamento de Urología, Instituto Nacional de Cancerología, Mexico City, 14080, México., Departamento de Bioquímica, Facultad de Medicina, UNAM, Mexico City, 04510, México., Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Mexico City, 14080, México. ., Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Mexico City, 14080, México. .