Background/Aim: The occurrence of germ cell tumour (GCT) in the elderly is rare, with scarce data available. The aim of this study was to understand the clinical outcomes of patients with GCT in patients aged > 45 years. Materials and Methods: A retrospective study was conducted in a large tertiary cancer centre in north-west London. Between 1 January 2003 and 31 March 2022, 108 cases of GCT in men aged > 45 years were identified and treated at the Mount Vernon Cancer Centre. The median age at diagnosis was 54 years (range = 45−70 years). Results: The 5-year survival rate of all patients was 96%, and the toxicity profile was similar to the younger age group. Conclusion: Older patients with GCT are able to tolerate chemotherapy; however, care must be taken to prevent life-threatening complications using appropriate dose modification.
Cancers. 2022 Oct 11*** epublish ***
Anand Sharma, Laura Morrison, Marina Milic, Aruni Ghose, Andrew Gogbashian, Nikhil Vasdev, Samita Agarwal, Ben Pullar, Gordon Rustin
Department of Medical Oncology, Mount Vernon Cancer Centre, London HA6 2RN, UK., Department of Radiology, Mount Vernon Cancer Centre, Paul Strickland Scanner Centre, London HA6 2RN, UK., Hertfordshire and Bedfordshire Urological Cancer Centre, Department of Urology, Lister Hospital, East and North Herts NHS Trust, Stevenage SG1 4AB, UK., Department of Histopathology, Lister Hospital, East and North Herts NHS Trust, Stevenage SG1 4AB, UK.