To elucidate the spectrum of metastatic solid tumors to the testis and their clinicopathologic features.
The databases and files of 26 pathology departments from 9 countries on 3 continents were surveyed to identify metastatic solid tumors to the testis and to characterize their clinicopathologic features in detail.
We compiled a series of 157 cases of metastatic solid tumors that secondarily involved the testis. The mean patient age at diagnosis was 64 years (range, 12 to 93 years). Most patients (127/144; 88%) had clinical manifestation of the disease, with testicular mass/nodule (89/127; 70%) being the most common finding. The main mechanism of testicular involvement was metastasis in 154/157 (98%) cases. Bilateral testicular involvement was present in 12/157 (8%) patients. Concurrent or prior extratesticular metastases were present in 78/101 (77%) patients. The diagnosis was made mainly in orchiectomy specimens (150/157; 95%). Different types of carcinomas (138/157; 87%), most commonly adenocarcinoma (72/157; 46%), were the most common malignancies. The most common primary carcinomas included prostatic (51/149; 34%), renal (29/149; 20%), and colorectal (13/149; 9%). Intratubular growth was identified in 13/124 (11%) cases and paratesticular involvement was found in 73/152 (48%) cases. In patients with available follow-up (110/157; 70%), more than half (58/110; 53%) died of disease.
In this largest series compiled to date, we found that most secondary tumors of the testis represent metastases from the genitourinary and gastrointestinal tract carcinomas and typically occur in the setting of disseminated disease.
No.
Human pathology. 2023 Jun 16 [Epub ahead of print]
Luiz M Nova-Camacho, Andres M Acosta, Kiril Trpkov, Ankur R Sangoi, Allaume Pierre, Angela Chou, Asli Yilmaz, Aurélien Morini, Ângelo Rodrigues, Christopher Dm Fletcher, Delia Perez-Montiel, Fiona Maclean, Félix Contreras, Francisco Javier Queipo, Gorka Muñiz Unamunzaga, Hector Mesa, Inés de Torres, Irune Ruiz, Isabel Alvarado-Cabrero, João Lobo, Lauren Schwartz, Liang Cheng, Mahmut Akgul, María García-Martos, Matthew B Palmer, Manju Aron, Maria Rosaria Raspollini, Manuel Manrique Celada, Michael Hwang, Muhammad T Idrees, Nathalie Rioux-Leclercq, Nicole Zalles, Norge Vergara, Priti Lal, Sara Wobker, Solène-Florence Kammerer-Jacquet, Susan Prendeville, Théau Tilmant, Thomas M Ulbright, Virginie Verkarre, Katrina Collins, Sean R Williamson, Angel Panizo
Department of Pathology, Donostia University Hospital, San Sebastian, 20014, Spain. Electronic address: ., Department of Pathology, Brigham and Women's Hospital, And Harvard Medical School, Boston, MA, 02115, USA; Department of Pathology, Faulkner Hospital, Boston, MA, 02130, USA., Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, T2V 1P9, Canada., Department of Pathology, El Camino Hospital, Mountain View, CA, 94040, USA., Department of Pathology, CHU Rennes - Hôpital Pontchaillou, Rennes, 35000, France., Department of Anatomical Pathology, Royal North Shore Hospital and University of Sydney, Sydney, 2065, Australia., Department of Pathology, Grand Hôpital de L'Est Francilien, Jossigny, Ile-de-France, 77600, France., Department of Pathology, Portuguese Oncology Institute of Porto, Porto, 4200-072, Portugal., Department of Pathology, Brigham and Women's Hospital, And Harvard Medical School, Boston, MA, 02115, USA., Department of Pathology, Instituto Nacional de Cancerología, Mexico City, 14080, Mexico., Department of Pathology and Laboratory Medicine, Douglass Hanly Moir Pathology, Sonic Healthcare, Sydney, 2000, Australia., Laboratorio de Patología, Clínica Universitaria Unión Médica, PUCMM, Santiago, 51000, Dominican Republic., Department of Pathology, San Jorge University Hospital, Huesca, 22004, Spain., Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Department of Pathology, Vall D'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, 08035, Spain., Department of Pathology, Donostia University Hospital, San Sebastian, 20014, Spain., Department of Pathology Oncology, Star Medica Hospital, Oncology Hospital, IMSS, Mexico City, 03810, Mexico., Department of Pathology, Portuguese Oncology Institute of Porto, Porto, 4200-072, Portugal; Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto) & Porto Comprehensive Cancer Center (P.CCC), Porto, 4200-072, Portugal; Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Porto, 4050-313, Portugal., Department of Pathology, University of Pennsylvania, Philadelphia, PA, 19104, USA., Department of Pathology and Laboratory Medicine, Brown University Warren Alpert Medical School, Providence, RI, 02903, USA., Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, 12208, USA., Department of Pathology, Gregorio Marañón University Hospital, Madrid, 28007, Spain., Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA., Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, 50134, Italy., Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH, 44106, USA., Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5S 1A1, Canada., Department of Pathology, European Georges Pompidou Hospital, Université Paris-Cité, Paris, 75015, France., Department of Pathology, University Hospital of Navarra, Pamplona, 31008, Spain.