The definition of the safest width of healthy renal margin to achieve oncological efficacy and therefore of the safest resection technique (RT) during partial nephrectomy (PN) continues to be widely debated.
The aim of this study is to evaluate the prevalence of positive surgical margins (PSM), loco-regional recurrence (LRR) and renal recurrence (RER) rates after simple enucleation (SE) and standard partial nephrectomy (SPN) for malignant renal tumors in studies with a minimum follow-up of 2 years.
A systematic review of the English-language literature was performed through August 2016 using the Medline, Web of Science and Embase databases according to the PRISMA criteria. A systematic review and meta-analysis was performed in those studies that defined the exact anatomical location of recurrence after PN.
Overall, 33 studies involving 11282 patients were selected for quantitative analysis. At a median follow up of 43 (SE) and 52 (SPN) months, the pooled estimates of the prevalence of PSMs, LRR and RER were 2.7% (95% CI: 1.5-4.6%, p<0.001) and0.4% (95% CI: 0.1-2.2%, p=0.018), 2.0% (95% CI: 1.4-2.8%, p<0.001) and 0.9% (95% CI: 0.5-1,7%p=0.04), 1.5% (95% CI: 0.9-2.3%, p=0.001) and 0.9% (95% CI: 0.5-1,7%, p=0.40) in patients undergoing SPN and SE, respectively.
Our systematic analysis and meta-analysis demonstrates that SE is noninferior to SPN regarding PSM, LRR and RER rates in patients undergoing PN for malignant renal tumors. Further studies using standardized reporting tools are needed to evaluate the role of resection techniques for oncologic outcomes after PN.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology. 2017 Jan 26 [Epub ahead of print]
Andrea Minervini, Riccardo Campi, Francesco Sessa, Ithaar Derweesh, Jihad H Kaouk, Andrea Mari, Koon H Rha, Maurizio Sessa, Alessandro Volpe, Marco Carini, Robert G Uzzo
Department of Urology, Careggi Hospital, University of Florence, Florence, Italy., Department of Urology, Careggi Hospital, University of Florence, Florence, Italy - ., Department of Urology, UC San Diego Health System, La Jolla, CA, USA., Department of Urology, Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH, USA., Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea., Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", II University of Naples, Naples, Italy., Department of Urology, University of Eastern Piedmont, Novara, Italy., Division of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.