BERKELEY, CA (UroToday.com) - Our report describes DLG7 as a predictor of high-risk prostate cancer. An early indication of DLG7’s prognostic value came from its similarity to DNA topoisomerase 2α (TOP2A). We found high correlation between the RNA levels of DLG7 and TOP2A (Pearson coefficient = 0.816, Figure 1). TOP2A is one of the strongest predictors of adverse outcome for ERG (-) high-risk prostate cancer (Cheville, Karnes, et al. 2008). Therefore, some predictive value of DLG7 for outcome in men at high-risk prostate cancer was anticipated from that similarity. Further analysis of the 150-pair Mayo case-control study revealed that the prognostic ability of DLG7 was better in ERG(-) than in ERG(+) cases. Furthermore, when both markers were incorporated into a model, the AUC increased.
Although our findings would require further validation, they suggest that the prognostic value of DLG7 depends on the ERG status. This is in agreement with recent literature indicating that prostate cancer can be stratified into two distinct subtypes, based on the ERG status.
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| Figure 1: Correlation between the RNA levels of DLG7 and TOP2A in prostate cancer patients. |
Written by:
George Vasmatzis, PhD1 and Christian Gomez, PhD2 as part of Beyond the Abstract on UroToday.com. This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations etc... of their research by referencing the published abstract.
1Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota USA
2University of Mississippi Medical Center, Jackson, Mississippi USA
Prognostic value of discs large homolog 7 transcript levels in prostate cancer - Abstract
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