Early salvage radiotherapy (SRT) is the standard of care for biochemical recurrence post-prostatectomy but outcomes are heterogeneous.
To develop a risk scoring system based on relevant standard-of-care clinico-pathological prognostic factors for patients treated with SRT with and without hormonal therapy (HT).
The Intermediate Clinical Endpoints in Cancer of the Prostate (ICECaP) database included three randomized trials (Individual patients' data from 1647 subjects) assessing SRT (GETUG-AFU-16; NRG/RTOG-9601, and a subset of EORTC-22911).
Outcomes were clinical progression (CP). metastasis free-survival (MFS) and overall survival (OS). Clinico-pathological factors, including pathological Gleason Score (GS), PSA at SRT start, margin status, persistent PSA post-RP and time from RP to SRT were evaluated by multivariable models stratified by type of treatment.
On multivariable analysis PSA ≥ 0.5 ng/mL at SRT start, GS ≥ 8 and negative margin status were the three strongest prognostic factors. Three prognostic groups defined by number of these risk features (high risk: 2 or 3; intermediate risk: 1 and low risk: 0) were strongly associated with OS, MFS and CP outcomes with SRT alone or with HT. This prognostic group definition was also relevant for patients with persistent PSA post RP and for patients treated < 1 year from RP to SRT and with and without HT.
A risk score for patients receiving SRT with or without HT, using three standard-of-care clinico-pathological risk factors provides refined prognostic information for individual patient counselling.
By using a composite score of pathology grading (Gleason Score), PSA at start of salvage radiation and margin status data, physicians can provide patients with more refined information on the risk of a second relapse after receiving radiation to the prostate bed after a prostatectomy for a rising or persistent PSA, both with and without hormonal therapy.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2024 Sep 13 [Epub ahead of print]
Pascal Pommier, Wanling Xie, Praful Ravi, Christian Carrie, James J Dignam, Felix Feng, Paul Sargos, Silke Gillessen Sommer, Daniel E Spratt, Bertrand Tombal, Hendrik Van Poppel, Christopher Sweeney
Department of Radiation Oncology, Curie Institute, Paris, France. Electronic address: ., Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Department of Radiation Oncology, Centre Léon Bérard, Lyon, France., The University of Chicago, Chicago, IL, USA., Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Department of Radiotherapy, Institut Bergonié, Bordeaux, France., Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Cliniques universitaires Saint Luc, Brussels, Belgium., Department of Urology, Katholieke Universiteit Leuven, Leuven, Belgium., South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, Australia.