MRI fusion prostate biopsy has improved the detection of clinically significant prostate cancer (CSC). Continued refinements in predicting the pre-biopsy probability of CSC are essential for optimal patient counseling. We investigated potential factors related to improved cancer detection rates (CDR) of CSC in patients with PI-RADS ≥ 3 lesions.
The pathology of 980 index lesions in 980 patients sampled by transrectal mpMRI-targeted prostate biopsy across four medical centers between 2017-2020 was reviewed. PI-RADS lesion distribution included 291 PI-RADS-5, 374 PI-RADS-4, and 315 PI-RADS-3. We compared CDR of index PI-RADS ≥ 3 lesions based on location (TZ) vs. (PZ), PSA density (PSAD), and history of prior negative conventional transrectal ultrasound-guided biopsy (TRUS).
Mean age, PSA, prostate volume, and level of prior negative TRUS biopsy were 66 years (43-90), 7.82 ng/dL (5.6-11.2), 54 cm3 (12-173), and 456/980 (46.5%), respectively. Higher PSAD, no prior history of negative TRUS biopsy, and PZ lesions were associated with higher CDR. Stratified CDR highlighted significant variance across subgroups. CDR for a PI-RADS-5 score, PZ lesion with PSAD ≥ 0.15, and prior negative biopsy was 77%. Conversely, the CDR rate for a PI-RADS-4 score, TZ lesion with PSAD < 0.15, and prior negative biopsy was significantly lower at 14%.
For index PI-RADS ≥ 3 lesions, CDR varied significantly based on location, prior history of negative TRUS biopsy, and PSAD. Such considerations are critical when counseling on the merits and potential yield of prostate needle biopsy.
Current oncology (Toronto, Ont.). 2024 Aug 01*** epublish ***
Ahmad N Alzubaidi, Amy Zheng, Mohammad Said, Xuanjia Fan, Michael Maidaa, R Grant Owens, Max Yudovich, Suraj Pursnani, R Scott Owens, Thomas Stringer, Chad R Tracy, Jay D Raman
Department of Urology, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA., Pennsylvania State College of Medicine, Hershey, PA 17033, USA., Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA., Department of Urology, University of Florida College of Medicine, Gainesville, FL 32611, USA., UPMC Central PA Hospital, Camphill, PA 17011, USA.