Altering the systemic milieu through exercise has been proposed as a potential mechanism underlying exercise-driven tumour suppression. It is not yet known whether men with advanced prostate cancer can elicit such adaptations following a program of exercise.
The purpose is to examine myokine levels of serum acquired from metastatic castrate-resistant prostate cancer (mCRPC) patients recruited to the INTERVAL-GAP4 trial before and after 6 months of exercise and its tumour-suppressive effect.
Twenty-five men with mCRPC (age = 74.7 ± 7.1 yrs) were randomised to supervised multimodal (aerobic and resistance) exercise (EX) or self-directed exercise control group (CON). Body composition was assessed using dual-energy x-ray absorptiometry (DXA), and fasting blood in a rested state was collected at baseline and at 6 months. Serum levels of myokines (SPARC, OSM, decorin, IGF-1, and IGFBP-3) were measured. Serum was applied to the prostate cancer cell line DU145, and growth was assessed for 72 h.
No significant change in body composition was observed. Adjusted serum OSM (P = 0.050) and relative OSM (P = 0.083), serum SPARC (P = 0.022) and relative SPARC (P = 0.025) increased in EX compared to CON. The area under curve (AUC) over 72 h showed a significant reduction in DU145 growth after applying post-intervention serum from the EX vs CON (P = 0.029).
Elevated myokine expressions and greater tumour-suppressive effects of serum after 6 months of periodised and autoregulated supervised exercise was observed in men with mCRPC. Exercise-induced systemic changes may slow disease progression in men with advanced prostate cancer.
Prostate cancer and prostatic diseases. 2022 Feb 12 [Epub ahead of print]
Jin-Soo Kim, Dennis R Taaffe, Daniel A Galvão, Nicolas H Hart, Elin Gray, Charles J Ryan, Stacey A Kenfield, Fred Saad, Robert U Newton
Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, 6027, Australia., School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia., Medical School, University of Minnesota, Minneapolis, MN, 55455, USA., Departments of Urology and Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, 94143, USA., Department of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, QC, H2X 3E4, Canada., Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, 6027, Australia. .
PubMed http://www.ncbi.nlm.nih.gov/pubmed/35152272
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