Research examining the association between physical activity (PA) and prostate cancer (PCa) has accumulated; however, few studies have examined this association in the context of active surveillance. The current study examines this among men initially diagnosed with favorable-risk PCa and managed by active surveillance at Sunnybrook Health Sciences Centre in Canada and the Royal Marsden Hospital in the United Kingdom.
Participants completed a questionnaire on daily participation in non-leisure, transport, and recreational PA. A logistic regression was employed using PA as the independent variable and whether the patient reclassified to higher-risk PCa while on active surveillance as the dependent variable. Demographic and lifestyle covariates were incorporated in the analysis to assess potential confounding and effect modification.
Men from both hospitals presented with similar clinical and demographic characteristics. Total PA was inversely associated with odds of reclassification while on active surveillance (p-trend = 0.027). A weaker inverse association was observed with recreational PA (p-trend = 0.30). Men who participated in weekly vigorous PA were less likely to reclassify than those who did not (odds ratio (95% confidence interval): 0.42 (0.20-0.85)).
Total and vigorous PA were inversely associated with odds of reclassification in two active surveillance cohorts. Given the limitations of this study, more robust prospective observational studies involving objective PA measures are warranted to confirm findings.
Prostate cancer and prostatic diseases. 2017 Dec 14 [Epub ahead of print]
David E Guy, Avi Vandersluis, Laurence H Klotz, Neil Fleshner, Alexander Kiss, Chris Parker, Vasundara Venkateswaran
Schulich School of Medicine and Dentistry, Western University, Toronto, ON, Canada., Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Division of Urology, Department of Surgery, Princess Margaret Hospital, Toronto, ON, Canada., Evaluative Clinical Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Institute of Cancer Research, Royal Marsden Hospital, Sutton, UK., Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. .