Apocrine carcinoma is a rare malignant adnexal neoplasm.
The differential diagnosis between apocrine carcinoma and cutaneous metastasis is often difficult. Here, we report a case of locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of the colon. A 75-year-old man with a history of surgical resection due to sigmoid colon cancer and penile metastasis two years prior to this study presented with a nodule at the left penile base. He underwent a wide local resection of the penile mass under a suggested preoperative diagnosis of extra-mammary Paget's disease (EMPD) associated with previous sigmoid colon cancer. However, the previously and currently resected penile masses were identified as primary apocrine carcinoma upon hematoxylin and eosin (H&E) staining and immunohistochemical staining. Although the incidence is extremely rare, both clinicians and pathologists should be alert to the possibility of synchronous double primary apocrine carcinoma in cancer patients with malignant cutaneous lesions.
Written by:
Lee OJ, Yun SJ, Kim WJ, Choi SY, Lee HC, Song HG, Lim SN, Lee KH, Kim ST, Han HS. Are you the author?
Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea; Department of Urology, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea; Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.
Reference: Chin J Cancer Res. 2013 Dec;25(6):777-80.
doi: 10.3978/j.issn.1000-9604.2013.12.11
PubMed Abstract
PMID: 24385708
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