Introduction: Penile cancer is rare, and data on prognostic factors of the disease are scarce.
The aim of the study was to assess prognostic factors in patients undergoing lymphadenectomy for penile cancer.
Material and Methods: Ninety-eight men who underwent lymphadenectomy for penile cancer were enrolled in the study. Progression-free survival and overall survival were assessed.
Results: Five-year progression-free survival and overall survival were 0.6651 (95% CI: 0.5151-0.7783) and 0.5516 (95% CI: 0.4412-0.6488), respectively. Multivariate analysis showed that the factors that reduce progression-free survival include delay of lymphadenectomy by more than 3 months after diagnosis (p = 0.045) and involvement of non-inguinal lymph nodes (N0 vs. affected lymph nodes other than superficial inguinal, p = 0.0004; superficial inguinal vs. others, p = 0.001). Factors deteriorating overall survival include high grade (G1 vs. G2, p = 0.0072, and G1 vs. G3, p = 0.0347), more than one lymph node affected (p = 0.001) and crossing the lymph node capsule (p = 0.034).
Conclusions: The factors worsening the prognosis in patients with penile cancer after lymphadenectomy include delayed lymphadenectomy, involvement of lymph nodes other than the superficial inguinal, involvement of more than one lymph node, crossing the lymph node capsule, and high grade.
Written by:
Wiechno P, Kalinowski T, Itrych B, Sikora-Kupis B, Demkow T, Karwański M. Are you the author?
Uro-Oncology Department, Maria Skłodowska-Curie Memorial Cancer Center, Warsaw, Poland.
Reference: Urol Int. 2013 Sep 17. Epub ahead of print.
doi: 10.1159/000353095
PubMed Abstract
PMID: 24051343
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