We investigated the feasibility of the tertiary lymphoid structure (TLS) as a prognostic marker for penile squamous cell carcinoma(SCC).
We retrospectively collected data from 83 patients with penile squamous cell carcinoma. H&E-stained slides were reviewed for TLS density. In addition, clinical parameters were analyzed, the prognostic value of these parameters on overall survival (OS) was evaluated using ‒ Kaplan-Meier survival curves, and the prognostic value of influencing factors was evaluated using Cox multifactor design nomogram analysis.
BMI, T, N, and M are significant in the survival curve with or without tertiary lymphoid structure. BMI, T, N, M and TLS were used to construct a prognostic model for penile squamous cell carcinoma, and the prediction accuracy reached a consensus of 0.884(0.835-0.932), and the decision consensus reached 0.581(0.508-0.655).
TLS may be a positive prognostic factor for penile squamous cell carcinoma, and the combination of BMI, T, N and M can better evaluate the prognosis of patients.
BMC urology. 2024 Aug 02*** epublish ***
Han Tang, Zhengwei Su, Qingming Huang, Yongpeng Li, Rongchao Chen, Chengjie Ban, Chanzhen Liu, Haoyuan Lu, Xian-Lin Yi, Yong Tang
Department of Urology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China., Department of Gynecology and Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China., Department of Urology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. ., Department of Urology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. .