The relation between adenine nucleotides and cancer has already been described in literature.
Considering that the enzymes ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) act together to control nucleotide levels, we aimed to investigate the role of these enzymes in prostate cancer (PCa). E-NPP and ADA activities were determined in serum and platelets of PCa patients and controls. We also verified the influence of the Gleason score, bone metastasis and treatment in the enzyme activities. Platelets and serum E-NPP activity increased, whereas ADA activity in serum decreased in PCa patients. In addition, Gleason score, metastasis and treatment influenced E-NPP and ADA activities. We may propose that E-NPP and ADA are involved in the development of PCa. Moreover, E-NPP and ADA activities are modified in PCa patients with distinct Gleason score, with bone metastasis, as well as in patients under treatment.
Written by:
Battisti V, Maders LD, Bagatini MD, Battisti IE, Bellé LP, Santos KF, Maldonado PA, Thomé GR, Schetinger MR, Morsch VM. Are you the author?
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, 97105-900 Santa Maria, RS, Brazil.
Reference: Biomed Pharmacother. 2013 Apr;67(3):203-8.
doi: 10.1016/j.biopha.2012.12.004
PubMed Abstract
PMID: 23433854
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