Many studies have reported the role of glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism with prostate cancer (PCa) risk.
However, these studies have yielded conflicting results. Hence, we performed this meta-analysis to investigate the association between GSTP1 Ile105Val polymorphism and PCa in different inheritance models. A total of 13 eligible studies were pooled into this meta-analysis. There was significant association between the GSTP1 Ile158Val variant genotypes and PCa for Ile/Ile vs Val/Val comparison [odds ratio (OR) = 0.705; I 2 = 63.7 %; 95 % confidence interval (95 % CI) = 0.508-0.977], Ile/Val vs Val/Val comparison (OR = 0.736; I 2 = 8.0 %; 95 % CI = 0.613-0.883), and dominant model (OR = 0.712; I 2 = 45.5 %; 95 % CI = 0.555-0.913). However, no associations were detected for other genetic models. In the stratified analysis by ethnicity, significant associations between GSTP1 Ile105Val polymorphism and PCa risk were also found among Caucasians (Ile/Ile vs Val/Val comparison OR = 0.818, I 2 = 0.0 %, 95 % CI = 0.681-0.982; Ile/Val vs Val/Val comparison OR = 0.779, I 2 = 0.0 %, 95 % CI = 0.651-0.933; and dominant model OR = 0.794, I 2 = 0.0 %, 95 % CI = 0.670-0.941), while there were no associations found for other genetic models. However, no associations were found in Asians and African-Americans for all genetic models when stratified by ethnicity. In conclusion, our meta-analysis indicates that GSTP1 Ile105Val polymorphisms contributed to the PCa susceptibility. However, a study with the larger sample size is needed to further evaluate gene-environment interaction on GSTP1 Ile105Val polymorphisms and PCa risk.
Written by:
Yu Z, Li Z, Cai B, Wang Z, Gan W, Chen H, Li H, Zhang P, Li H. Are you the author?
Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Reference: Tumour Biol. 2013 Mar 14. Epub ahead of print.
doi: 10.1007/s13277-013-0727-x
PubMed Abstract
PMID: 23494181
UroToday.com Investigative Urology Section
