Objective: The objective of this study is to examine our current understanding of molecular mechanisms involved in regulation of CYP genes to induce bladder cancer by endogenous and exogenous chemicals and to analyze the respective polymorphisms in various isoforms of xenobiotic-metabolizing gene involved in bladder cancer.
Methods: Studies revealed the molecular mechanisms of CYP genes and respective polymorphisms to demonstrate the association between xenobiotic-metabolizing gene polymorphisms and bladder cancer published from 1996 through 2012 were retrieved from MEDLINE, EMBASE and PUBMED databases.
Results: 22 studies met our criteria of CYP polymorphism and bladder cancer. We found that a large proportion of the published studies were small and population-based.
Conclusion: We conclude that large, well-designed studies of common polymorphisms in CYP genes are needed. Such studies may benefit from analysis of multiple genes or polymorphisms and from the consideration of relevant exposures.
Written by:
Sankhwar M, Sankhwar SN. Are you the author?
Dept. of Urology, King George Medical University, Lucknow 226003, India.
Reference: Urol Oncol. 2013 Feb 18. pii: S1078-1439(12)00351-1.
doi: 10.1016/j.urolonc.2012.10.005
PubMed Abstract
PMID: 23428537
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