Microbial transformation of 20(S)-protopanaxadiol (1) by Mucor racemosus AS 3.205 yielded two novel hydroperoxylated metabolites and three known hydroxylated metabolites.
The structures of the metabolites were identified as 26-hydroxyl-20(S)-protopanaxadiol (2), 23,24-en-25-hydroxyl-20(S)-protopanaxadiol (3), 25,26-en-24(R)-hydroperoxyl-20(S)-protopanaxadiol (4), 23,24-en-25-hydroperoxyl-20(S)-protopanaxadiol (5), and 25-hydroxyl-20(S)-protopanaxadiol (6). 4 and 5 are new compounds. Metabolites 2, 4, and 5 showed the more potent inhibitory effects against DU-145 and PC-3 cell lines than the substrate.
Written by:
Chen G, Yang X, Nong S, Yang M, Xu B, Zhang W. Are you the author?
School of Medicine, Nantong University, Nantong, 226001, People's Republic of China.
Reference: Biotechnol Lett. 2013 Mar;35(3):439-43.
doi: 10.1007/s10529-012-1098-x
PubMed Abstract
PMID: 23183919
UroToday.com Investigative Urology Section
