Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma.
Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and higher pI values compared to isoforms found in the control group.
Written by:
Shin EF, Vodolazhsky DI, Golikov AY, Belova TN, Boyko NV, Zimakov DV, Cherkasova EN, Kogan MI, Chibichian MB, Moshkovskii SA, Tarasov VA, Matishov DG. Are you the author?
Institute of Arid Zones, Southern Scientific Center of the Russian Academy of Sciences, 344006 Rostov-on-Don, Russia.
Reference: Biochemistry (Mosc). 2012 Sep;77(9):1065-71.
doi: 10.1134/S0006297912090143
PubMed Abstract
PMID: 23157267
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