The first synthesis of (+)-myrrhanol C (1), an antitumor polypodane-type bicyclic triterpene with inhibitory activity against androgen insensitive prostate cancers, is reported herein (IC50 10 μmolar).
A key step in our convergent synthesis of (+)-myrrhanol C and related analogues is the employment of a microbial stereo- and regioselective late stage C-H oxidation. A low-waste and sustainable process has been developed to prepare (+)-myrrhanol C for further biological studies.
Written by:
Domingo V, Lorenzo L, Quilez del Moral JF, Barrero AF. Are you the author?
Department of Organic Chemistry, Institute of Biotechnology, Faculty of Sciences, University of Granada, Campus de Fuente Nueva, s/n, 18071 Granada, Spain.
Reference: Org Biomol Chem. 2013 Jan 28;11(4):559-62.
doi: 10.1039/C2OB26947C
PubMed Abstract
PMID: 23147747
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