Metastasis is the primary mediator of prostate cancer (PCA) lethality and poses a significant clinical obstacle.
The identification of factors involved in the metastasis of PCA is imperative. We demonstrate herein that trefoil factor 1 (TFF1) promotes PCA cell migration and invasion in vitro and metastasis in vivo. The capacity of TFF1 to enhance cell migration/invasion is mediated by transcriptional repression of E-CADHERIN. Consideration of targeted inhibition of TFF1 to prevent metastasis of prostate carcinoma is warranted.
Written by:
Bougen NM, Amiry N, Yuan Y, Kong XJ, Pandey V, Vidal LJ, Perry JK, Zhu T, Lobie PE. Are you the author?
Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Reference: Cancer Lett. 2012 Dec 22. pii: S0304-3835(12)00729-X(Epub ahead of print)
doi: 10.1016/j.canlet.2012.12.012
PubMed Abstract
PMID: 23266572
