Here we studied the cellular mechanisms of ursolic acid's anti-bladder cancer ability by focusing on endoplasmic reticulum stress (ER stress) signaling.
We show that ursolic acid induces a significant ER stress response in cultured human bladder cancer T24 cells. ER stress inhibitor salubrinal, or PERK silencing, diminishes ursolic acid-induced anti-T24 cell effects. Salubrinal inhibits ursolic acid-induced CHOP expression, Bim ER accumulation and caspase-3 activation in T24 cells. Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. We suggest that ER stress contributes to ursolic acid's effects against bladder cancer cells.
Written by:
Zheng QY, Li PP, Jin FS, Yao C, Zhang GH, Zang T, Ai X. Are you the author?
Department of Urology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
Reference: Cell Signal. 2013 Jan;25(1):206-13.
doi: 10.1016/j.cellsig.2012.09.012
PubMed Abstract
PMID: 23000344
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