AIMS: To assess the prognostic utility of semi-quantiative expression of RhoC protein in whole prostates from patients who had radical prostatectomies for high grade prostate cancer (PCa).
METHODS: Subjects who had surgery >55 months previously with primary Gleason pattern 4 PCa were identified from practice records, archival tissues were retrieved for review and RhoC immunohistochemistry, and ZAG expression was also assessed as a control.
RESULTS: Eighty-nine subjects were included in the study; 57 had a rising prostate specific antigen (PSA) post-operatively ('cases') and 32 did not ('controls'). By univariate analysis, expression of both RhoC and ZAG proteins was greater in controls than cases, but this was significant only for ZAG. By multivariate analysis, Gleason variables (patterns and score), extraprostatic extension and decreased RhoC staining all contributed to predicting PSA failure (pā<ā0.05). ZAG expression was inversely correlated with Gleason pattern and hence was not independently predictive in our multivariate model.
CONCLUSIONS: Increased RhoC expression predicted a good outcome after radical prostatectomy. ZAG staining also correlated with a favourable outcome but was not independently predictive due to its relationship with Gleason pattern.
Written by:
Mills J, Oliver A, Sherwin JC, Frydenberg M, Peters JS, Costello A, Harewood L, Love C, Redgrave N, van Golen KL, Bailey M, Pedersen J. Are you the author?
TissuPath Specialist Pathology, Mount Waverley; Department of Medicine, Central Clinical School, Monash University, Melbourne; Department of Surgery, Monash University, Clayton; Epworth Hospital, Richmond; Australian Prostate Cancer Research Centre at Epworth Hospital, Richmond; University of Melbourne, Parkville and Epworth Health Care Group, Richmond; Bayside Urology, Mentone; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne; Alfred Hospital, Melbourne, and Monash University Faculty of Medicine, Melbourne, Victoria, Australia; Department of Biological Sciences, University of Delaware, Newark, DE, USA.
Reference: Pathology. 2012 Oct;44(6):513-518.
PubMed Abstract
PMID: 22935975
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