Seven hydroxylates of 20(S)-protopanaxatriol (1) transformed by Absidia corymbifera AS 3.3387 were isolated and identified by spectral methods including 2D-NMR.
Among them, 7β-hydroxyl-20(S)-protopanaxatriol (2), 7α-hydroxyl-20(S)-protopanaxatriol (3), and 7β, 15α-dihydroxyl-20(S)-protopanaxatriol (7) are new compounds. The metabolites 2, 6, 7, and 8 showed the more potent inhibitory effects against DU-145 and PC-3 cell lines than the substrate
Written by:
Chen G, Yang X, Zhai X, Yang M Are you the author?
School of Medicine, Nantong University, Nantong, 226001, People's Republic of China,
Reference: Biotechnol Lett. 2012 Sep 18
PubMed Abstract
PMID: 22986539
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