We have investigated the role of bone-morphogenetic protein (BMP) 2 and tumor necrosis factor α (TNF-α) in 33 patients with bladder cancer (BCa) with bone metastasis.
Thirty nonmetastatic BCas were included as controls. Immunohistochemical staining with BMP-2 and TNF-α was performed. Expressions of the factors were quantified and studied statistically. As a result, a trend showing higher expression of BMP-2 and TNF-α was associated with advanced disease. Expressions of BMP-2 and TNF-α were significantly higher in BCa with bone metastases (P = .0002 and P = .0172, respectively). The expression of BMP-2 and TNF-α showed a direct correlation in metastatic and muscle-invasive cases (P = .0202 and P = .0004, respectively) but not in nonmetastatic or noninvasive BCa (P = .1834 and P = .9215, respectively). It is postulated that BMP-2 can be responsible for the mechanism involved in triggering bone metastasis in BCa. The correlation with TNF-α indicates that the interaction of the 2 factors may promote local invasion and distant metastasis, especially to bone.
Written by:
Yang ZJ, Liu FX, Yang YS, Yang X, Zhu GX. Are you the author?
Division of Orthopedia, Second People's Hospital of Wuxi, Nanjing Medical University, Wuxi 214000, PR China.
Reference: Ann Diagn Pathol. 2012 Jun 29. Epub ahead of print.
doi: 10.1016/j.anndiagpath.2012.05.008
PubMed Abstract
PMID: 22748688
UroToday.com Investigative Urology Section
