Using a series of detailed experiments, Zhang and colleagues establish that the prostate cancer RNA chimera SLC45A3-ELK4 is generated by cis-splicing between the 2 adjacent genes and does not involve DNA rearrangements or trans-splicing.
The chimera expression is induced by androgen treatment likely by overcoming the read-through block imposed by the intergenic CCCTC insulators bound by CCCTC-binding factor repressor protein. The chimeric transcript, but not wild-type ELK4, is shown to augment prostate cancer cell proliferation.
Written by:
Kumar-Sinha C, Kalyana-Sundaram S, Chinnaiyan AM. Are you the author?
Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Reference: Cancer Discov. 2012 Jul;2(7):582-5.
doi: 10.1158/2159-8290.CD-12-0212
PubMed Abstract
PMID: 22787087
UroToday.com Investigative Urology Section
