Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions.
This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinical value in the analysis of prostate biopsies, including diagnosis, monitoring progression during active surveillance, and assessing efficacy of presurgical neoadjuvant and focal therapeutic interventions.
Written by:
Trujillo KA, Jones AC, Griffith JK, Bisoffi M. Are you the author?
Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Reference: Prostate Cancer. 2012;2012:302894.
doi: 10.1155/2012/302894
PubMed Abstract
PMID: 22666601
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