Introduction: Peyronie's disease (PD) is a fibromatosis of the penis, with a pathology very similar to what is seen in the hand (palmar fascia) in Dupuytren's disease (DD).
Recently, we performed a genome-wide association study and identified nine genetic loci containing common variants associated with DD. Seven of these loci mapped within or near genes of the canonical WNT pathway and each locus yielded relatively large odds ratios (ORs) for DD disease status.
Aim: Given the clinical overlap between PD and DD, we examined whether the nine DD susceptibility loci are also involved in PD.
Methods:An association study was performed using a case/control design. From 2007 to 2010, we prospectively included 111 men who had been clinically diagnosed with PD. Control subjects (N = 490 males) were randomly drawn from a population-based cohort from the same region of the Netherlands. Allele frequencies in the 111 PD cases and 490 controls were compared using a 1-degree-of-freedom basic chi-square test. A P value < 0.05 after Bonferroni correction for the nine tested single nucleotide polymorphisms (SNPs) was considered statistically significant (i.e., P < 0.0056).
Main Outcome Measure: Association of genetic markers (SNPs) with PD. Results. We observed significant association with SNP rs4730775 at the wingless-type MMTV integration site family member 2 (WNT2) locus on chromosome 7 (P = 0.0015, OR 0.61), but found no evidence for the other eight loci being involved with PD despite the large effect size seen for some of these variants in DD. The WNT2 association was even more significant after we removed 15 patients with comorbid DD.
Conclusions: WNT2 is a susceptibility locus for PD and our finding provides evidence for a partly shared genetic susceptibility between PD and DD.
Written by:
Dolmans GH, Werker PM, de Jong IJ, Nijman RJ; LifeLines Cohort Study, Wijmenga C, Ophoff RA. Are you the author?
Department of Plastic Surgery, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands; Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands; Department of Urology, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands; Center for Neurobehavioral Genetics, University of California, Los Angeles, CA, USA; Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherland.
Reference: J Sex Med. 2012 Apr 10. Epub ahead of print.
doi: 10.1111/j.1743-6109.2012.02704.x
PubMed Abstract
PMID: 22489561