Department of Epidemiology, Harvard School of Public Health, Building 2, Room 249B, 655 Huntington Ave, Boston, MA, 02115, United States.
A recent Genome-Wide Association Study (GWAS) of prostate cancer in a Japanese population identified five novel regions not previously discovered in other ethnicities. In this study, we attempt to replicate these five loci in a series of nested prostate cancer case-control studies of European ancestry.
We genotyped five SNPs: rs13385191 (chromosome 2p24), rs12653946 (5p15), rs1983891 (6p21), rs339331 (6p22) and rs9600079 (13q22), in 7,956 prostate cancer cases and 8,148 controls from a series of nested case-control studies within the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). We tested each SNP for association with prostate cancer risk and assessed if associations differed with respect to disease severity and age of onset.
Four SNPs (rs13385191, rs12653946, rs1983891 and rs339331) were significantly associated with prostate cancer risk (p-values ranging from 0.01 to 1.1x10-5). Allele frequencies and odds ratios were overall lower in our population of European descent compared to the discovery Asian population. SNP rs13385191 (C2orf43) was only associated with low-stage disease (p=0.009, case-only test). No other SNP showed association with disease severity or age of onset. We did not replicate the 13q22 SNP, rs9600079 (p=0.62).
Four SNPs associated with prostate cancer risk in an Asian population are also associated with prostate cancer risk in men of European descent.
Written by:
Lindström S, Schumacher F, Campa D, Demetrius A, Andriole GL, Berndt SI, Bueno-de-Mesquita HB, Chanock SJ, Diver WR, Gaziano JM, Gapstur SM, Giovannucci EL, Haiman CA, Henderson BE, Hunter DJ, Johansson M, Kolonel LN, Le Marchand L, Ma J, Stampfer MJ, Stevens VL, Trichopoulos D, Virtamo J, Willett WC, Yeager M, Hsing AW, Kraft P. Are you the author?
Reference: Cancer Epidemiol Biomarkers Prev. 2011 Nov 4. Epub ahead of print.
doi: 10.1158/1055-9965.EPI-11-0870-T
PubMed Abstract
PMID: 22056501
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