Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Loss of the Y chromosome is a frequently reported chromosomal abnormality in many tumor types. This study was undertaken to investigate the frequency of Y chromosome losses and this chromosomal abnormality might play a potential role in prostate cancer.
A preexisting prostate cancer tissue microarray (TMA) containing samples of 3,261 patients treated by radical prostatectomy with clinical follow-up data was used in this study. TMA sections were analyzed by fluorescence in situ hybridization (FISH) using a dual labeling probe for the centromeres of the X and Y chromosome.
Unequivocal losses of the Y chromosome were seen in only 12 of 2,053 analyzable cases. No significant associations were found between Y loss and patient age, pT stage, and the risk of PSA recurrence. Interestingly, in our study the presence of Y losses was significantly associated with high Gleason grade (P = 0.0034).
Loss of the Y chromosome is a rare event in prostate cancer. Y losses occur in much higher rates in most other cancer types. For this reason, we suggest that the expression of at least one Y chromosome gene is essential for prostate epithelial cells and it is possible that such a gene could represent a suitable target for future therapy of prostate cancer.
Written by:
Stahl PR, Kilgué A, Tennstedt P, Minner S, Krohn A, Simon R, Krause GV, Izbicki J, Graefen M, Sauter G, Schlomm T, Wilczak W. Are you the author?
Reference: Prostate. 2011 Sep 28. Epub ahead of print.
doi: 10.1002/pros.21492
PubMed Abstract
PMID: 21956681
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