Department of Pathology, Department of Urology, Erasmus Medical Center, Rotterdam, the Netherlands.
Department of Urology, Skåne University Hospital Malmö, Lund University, Malmö, Sweden.
To investigate whether cysteine-rich secretory protein 3 (CRISP-3) and/or β-microseminoprotein (β-MSP) expression in diagnostic prostate needle biopsies have predictive value for prostate cancer (PC) on radical prostatecomy (RP). To evaluate their potential clinical implementation in a preoperative setting.
In total, 174 participants from the European Randomized Study of Screening for Prostate Cancer, Rotterdam section, treated by RP for PC were included in the present study. CRISP-3 and β-MSP immunohistochemistry was performed on corresponding diagnostic needle biopsies. Outcome was correlated with clinicopathological parameters (prostate-specific-antigen, PSA; number of positive biopsies; Gleason score, GS; pT-stage; surgical margins at RP) and significant PC at RP (pT3/4, or GS > 6, or tumour volume ≥0.5 mL) in the total cohort (n= 174) and in a subgroup with low-risk features at biopsy (PSA ≤ 10 ng/ml, cT ≤ 2, PSA density <0.20 ng/mL/g, GS < 7 and ≤2 positive biopsy cores; n= 87).
β-MSP and CRISP-3 expression in PC tissue was heterogeneous, with variable staining intensities occurring in the same tissue specimen. High expression of β-MSP significantly correlated with GS < 7 at RP; it was not a predictor for significant PC at RP neither in the total group (n= 174; odds ratio, OR, 0.319; 95% confidence interval, CI, 0.060-1.695; P= 0.180), nor in the low-risk group (n= 87; OR, 0.227; 95% CI, 0.040-1.274; P= 0.092). CRISP-3 expression was not related to clinicopathological parameters, and did not predict significant PC at RP in the total group (n= 174; OR, 1.056; 95% CI, 0.438-2.545; P= 0.904) or the low-risk group (n= 87; OR, 1.856; 95% CI, 0.626-5.506; P= 0.265).
High β-MSP expression correlated with low GS in subsequent RP specimens, supporting the view that β-MSP exerts a tumour-suppressive effect. No significant prognostic value of β-MSP or CRISP-3 in prostate needle biopsies for significant PC at RP was found. β-MSP or CRISP-3 do not have additional value in the therapeutic stratification of patients with PC.
Written by:
Hoogland AM, Dahlman A, Vissers KJ, Wolters T, Schröder FH, Roobol MJ, Bjartell AS, van Leenders GJ. Are you the author?
Reference: BJU Int. 2011 Mar 16. Epub ahead of print.
doi: 10.1111/j.1464-410X.2010.10059.x
PubMed Abstract
PMID: 21410630
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